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GenomicsCentrosome amplification triggers tumorigenesis in p53 deficient epidermis
While aneuploidy is found in more than 90% of solid tumors, it is unclear whether aneuploidy is the cause or the consequence of tumorigenesis. Different mouse models deficient in centrosomal or spindle checkpoint proteins that induce aneuploidy show either a promotion or a decrease in tumorigenesis ...
ORGANISM(S): Mus musculus 
2015-10-27 | E-MTAB-3733 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomics of elderly mouse anterior pituitary in steady-state conditions and after transgenically inflicted local damage
The mouse pituitary gland houses a stem cell compartment which is known to suffer from an inflammatory phenotype at middle age (12-15 months), a process commonly referred to as ‘inflammaging’. Here, we investigate the aging pituitary stem cell phenotype by using single-cell RNA-sequencing interrogat...
ORGANISM(S): Mus musculus 
2025-01-06 | E-MTAB-14067 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomics of pituitary stem cell-derived organoid model
The pituitary is the master endocrine gland regulating key physiological processes and houses a stem cell compartment. Despite the application of transgenic in vivo approaches, the pituitary stem cells' phenotype, biology, and role remain unclear. To tackle this question, organoids were developed as...
ORGANISM(S): Mus musculus 
2025-01-01 | E-MTAB-14008 | biostudies-arrayexpress
GenomicsVIB VRC Data Access Committee
Data Access Committee EGAC00001000042
EGAC00001000042 | EGA
TranscriptomicsSingle-cell transcriptomics of wild-type and cystic fibrosis (F508del/del) mouse uterus
Female cystic fibrosis (CF) patients are confronted with fertility deficiency, experiencing difficulties in getting pregnant. Previous findings using CF mouse models indicate that CF negatively impacts female fertility in mice as it does in humans. Underlying reasons remain elusive. In particular, i...
ORGANISM(S): Mus musculus 
2025-10-31 | E-MTAB-14455 | biostudies-arrayexpress
GenomicsDAC EGAS00000000094
Data Access Committee EGAC00001000041
EGAC00001000041 | EGA
TranscriptomicsGenomic landscape of carcinogen induced mouse skin squamous cell carcinoma: RNA-sequencing
RNA-sequencing of induced murine squamous cell carcinoma.
ORGANISM(S): Mus musculus 
2015-04-16 | E-MTAB-2889 | biostudies-arrayexpress
TranscriptomicsGenomic landscape of carcinogen induced mouse skin squamous cell carcinoma: whole-genome sequencing
Low coverage whole-genome sequencing of induced murine squamous cell carcinoma. 17 samples are included.
ORGANISM(S): Mus musculus 
2015-04-10 | E-MTAB-2888 | biostudies-arrayexpress
GenomicsGenomic landscape of carcinogen induced mouse skin squamous cell carcinoma: whole-exome sequencing
Whole-exome sequencing of induced murine squamous cell carcinoma. 26 samples are included.
ORGANISM(S): Mus musculus 
2014-09-11 | E-MTAB-2887 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human breast cancer during pregnancy
Using a dataset of 54 pregnant and 113 age/stage-matched non-pregnant breast cancer patients with complete clinical and survival data; we evaluated the pattern of hot spot somatic mutations and performed transcriptomic profiling using Sequenom® and Affymetrix®, respectively. Breast cancer molecular ...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-53031 | biostudies-arrayexpress
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