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TranscriptomicsCryptochromes mediate rhythmic repression of the glucocorticoid receptor
The circadian transcriptional repressors cryptochromes 1 (Cry1) and 2 (Cry2) interact with the C-terminus of the glucocorticoid receptor (GR) and are required for transrepression in response to the synthetic GR ligand dexamethasone (Dex) in mouse embryonic fibroblasts. Dex induction of many genes w...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-24469 | biostudies-arrayexpress
ProteomicsThe circadian E3 ligase complex SCFFBXL3+CRY targets TLK2
We recently demonstrated that the circadian clock component CRY2 is an essential cofactor in the SCFFBXL3-mediated ubiquitination of c-MYC. Because our demonstration that CRY2 recruits phosphorylated substrates to SCFFBXL3 was unexpected, we investigated the scope of this role by searching for addit...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009522 | Pride
Circadian clock 
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