Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse splenic and small intestine lamina propria macrophages
The intestinal immune system must elicit robust immunity against harmful pathogens but restrain immune responses directed against commensal microbes and dietary antigens. The mechanisms that maintain this dichotomy are poorly understood. Here we describe a population of CD11b+F4/80+CD11câ?? macroph...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8868 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile in RAG2+ B lineage cells from the small intestinal lamina propria and RAG2+ B lineage cells from the bone marrow
We used a RAG2-GFP reporter mouse to show that RAG+ B lineage cells can be found in the small intestinal lamina proria in normally-housed mice at weaning age. We used microarry expression analysis to compare the RAG2+ population in the gut to the RAG2+ B lineage population in the bone marrow. Microa...
ORGANISM(S): Mus musculus 
2013-07-12 | E-GEOD-48805 | biostudies-arrayexpress
TranscriptomicsHigh throughput sequencing of immunoglobulin (Ig) heavy (IgH) and light (IgL) chain repertoires
We used 454 sequencing to assess the repertoire of B cell subsets from bone marrow, spleen, and small intestinal lamina propria from two mouse strains. We used a RAG2-GFP reporter mouse strain (129Sve background) to isolate CD19+ RAG2+ B lineage cells from bone marrow and small intestinal lamina pro...
ORGANISM(S): Mus musculus 
2013-07-16 | E-GEOD-48870 | biostudies-arrayexpress
TranscriptomicsmiRNAs expressed in murine CD4+ T cells of splenocyte and lamina propria lymphocytes
The levels of some murine mRNAs and proteins are expressed discrepantly between the central immune system and the gut immune system in murine colitis. It was possible that RNA interference would result in some of the discrepancy. Thus, we compared microRNAs that are expressed in CD4+ T cells of sple...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-40891 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of CD14+ CD163high CD160high cells in human intestinal lamina propria
Several innate immune cell subsets have recently been identified to maintain gut homeostasis in both human and mice. Among these subsets, CX3CR1high CD11b+ CD11c+ cells contribute to intestinal tolerance through various mechanisms in mice. However, whether tolerogenic innate myeloid cells are presen...
ORGANISM(S): Homo sapiens 
2016-07-17 | E-GEOD-79627 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of CD14+ CD163low cells in human intestinal lamina propria
Mouse intestinal innate immune cells have been identified as inducing Th17 cell differentiation. However, few studies have investigated innate immune cells that are involved in CD (Crohn's disiease) pathogenesis in humans. The present study aimed to identify a human intestinal lamina propria cell su...
ORGANISM(S): Homo sapiens 
2013-08-24 | E-GEOD-49066 | biostudies-arrayexpress
TranscriptomicsExpression data from GPR15+CD4+ and GPR15-CD4+ T cells in LILP
GPR15 is an orphan G-protein coupled receptor and its expression is abundant among T cells in the large intestine lamina propria. We used microarrays to examine charateristics of GPR15- vs GPR15+ CD4+ T cells in LILP and identified distinct classes of up-regulated genes in GPR15+ CD4+ T cells. We ha...
ORGANISM(S): Mus musculus 
2013-05-09 | E-GEOD-45773 | biostudies-arrayexpress
TranscriptomicsComparison of splenic and small intestine lamina propria dendritic cells
This SuperSeries is composed of the following subset Series: GSE22127: Expression profiling of small intestine lamina propria dendritic cells GSE22128: Expression profiling of splenic dendritic cells Dendritic cells play a vital role in initiating robust immunity against pathogens as well as mainta...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-22136 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of Th17 cells, isolated from the lamina propria of the large intestine from 3-6 month old IL-17GFP KI mice
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75106 | biostudies-arrayexpress
TranscriptomicsExpression profiling of small intestine lamina propria dendritic cells
Dendritic cells play a vital role in initiating robust immunity against pathogens as well as maintaining immunological tolerance to self antigens, food antigens and intestinal commensals. However, the intracellular signaling networks that program DCs to become tolerogenic are largely unknown. To add...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-22127 | biostudies-arrayexpress
Sort   by:  
 Page size