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MetabolomicsIntegrated Proteomics and Metabolomics Analysis Reveals Differential Lipid Metabolism in HUVEC under high and low shear stress
OBJECTIVE: Atherosclerotic plaque development is closely associated with the hemodynamic forces applied to endothelial cells (EC). Among these, shear stress (SS) plays a key role in disease development since changes in flow intensity and direction could stimulate an atheroprone or athero...
2019-07-25 | MTBLS739 | MetaboLights
TranscriptomicsTranscription profiling by array of human young and senescent HUVECs under static and laminar shear stress conditions
Laminar shear stress due to constant blood flow is known to play a critical role in maintaining vascular health. In contrast, endothelial cell senescence appears to be closely associated with the incidence of vascular disorder. In an attempt to identify functional biomarkers for age-related vascular...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-13712 | biostudies-arrayexpress
TranscriptomicsRNA seq of fluid shear stress treated mouse renal epithelial cells
Renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized renal proximal tubular epithelial cell line. Cells were exposed to l...
ORGANISM(S): Mus musculus 
2018-03-15 | E-MTAB-6640 | biostudies-arrayexpress
TranscriptomicsRNA seq of fluid shear stress treated mouse Pkd1-/- renal epithelial cells
Pkd1-/- renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized Pkd1-/- renal proximal tubular epithelial cell line. Cells w...
ORGANISM(S): Mus musculus 
2019-03-01 | E-MTAB-6641 | biostudies-arrayexpress
GenomicsLaminar shear stress regulated gene expression in HUVECs
Laminar shear stress regulated gene expression in HUVECs
PRJNA702756 | ENA
GenomicsLaminar shear stress regulated gene expression in HUVECs II
Laminar shear stress regulated gene expression in HUVECs II
PRJNA992551 | ENA
ProteomicsProteomic profiling of hCMEC/D3 cells exposed 3 days to laminar physiological shear stress
Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived from the blood circulation, including shear stress (SS). EC are able to detect SS and consequently adapt their phenotype, thus affecting many endothelial functions. If a plethora of shear stress-regulated molecu...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD030493 | Pride
Q-exactive  endothelial cells  bottom up lfq proteomics  shear stress  blood-brain barrier  brain microvessels 
GenomicsCircRNA profiling in laminar shear stress-treated human umbilical vein endothelial cells.
CircRNA profiling in laminar shear stress-treated human umbilical vein endothelial cells.
PRJNA950906 | ENA
TranscriptomicsTissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle
Tissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle Cells and Affects Cell Proliferation and Survival Introduction: Vascular smooth muscle cells (SMCs) are exposed to fluid shear stress (FSS) after interventional procedures such as balloon-angioplasty. Wher...
ORGANISM(S): Rattus norvegicus 
2010-04-12 | E-GEOD-19909 | biostudies-arrayexpress
GenomicsEndothelial Cell Cycle Responses to Laminar Shear Stress
Endothelial Cell Cycle Responses to Laminar Shear Stress
PRJNA880528 | ENA
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