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TranscriptomicsQuantitative Analysis by Next Generation Sequencing of LSK (Lin- Sca1+ cKit+) hematopoietic progenitors and splenic B cells (naive and in vitro LPS activated) transcriptomes from Wild Type and Usp3-/- mice
Purpose: the goal of this study is to investigate the consequences of USP3 deletion on gene expression in mouse LSK hematopoietic progenitors and in splenic B cells Methods: mRNA profiles of 8 weeks-old wild-type (WT) and ubiquitin specific protease 3 knockout (Usp3−/−) mice were generated by deep ...
ORGANISM(S): Mus musculus 
2014-07-24 | E-GEOD-58495 | biostudies-arrayexpress
TranscriptomicsFunctional Identification of Critical Bmi1 target genes in Neural Progenitor and Malignant Glioma cells
In this study, we combined a genome-wide analysis of the Polycomb protein Bmi1 and an in vivo RNAi screening to identify critical targets whose repression in neural progenitor and Malignant Glioma cells enables normal and aberrant self-renewal. Bmi1 ChIP-sequencing generated in 2 primary adult mouse...
ORGANISM(S): Mus musculus 
2013-05-21 | E-GEOD-33912 | biostudies-arrayexpress
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