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GenomicsEpigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues (ChIP-Seq and MeDIP-Seq)
DNA methylation has been comprehensively profiled in normal and cancer cells, but the dynamics that form, maintain and reprogram differentially methylated regions remain enigmatic. We show that methylation patterns within populations of cells from individual somatic tissues are heterogeneous and pol...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-41048 | biostudies-arrayexpress
GenomicsEpigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues
This SuperSeries is composed of the following subset Series: GSE41048: Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues (ChIP-Seq and MeDIP-Seq) GSE41049: Epigenetic polymorphism and the stochastic formation of differentially m...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-41050 | biostudies-arrayexpress
TranscriptomicsRobust 4C-seq data analysis to screen for regulatory DNA interactions
Regulatory DNA elements can control expression of distant genes via physical interactions. Here, we present a cost-effective methodology and computational analysis pipeline for robust characterization of the physical organization around selected promoters and other functional elements using Chromoso...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-40420 | biostudies-arrayexpress
TranscriptomicsFunctional enhancers at the gene-poor 8q24 cancer-linked locus
Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities have been unknown. Here we profiled a 5-megabase chromatin segment encompassin...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-19561 | biostudies-arrayexpress
Transcriptomicsp53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation
Analysis of miRNA expression in human breast cancer samples with Agilent's miRNA arrays. These samples are part of a study where we have investigated the mammalian cell proliferation control network consisting of transcription regulators, E2F and p53, their targets, and a family of 14 microRNAs. We ...
ORGANISM(S): Homo sapiens 
2008-09-22 | E-GEOD-12848 | biostudies-arrayexpress
Transcriptomicsp53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation
miRNA expression profiles of WI38 primary human fibroblasts with an active or inactive p53. Cells were compared under normal untreated conditions (young and proliferating cells), after DNA damage with Doxorubicin, and upon entry into replicative senescence. Keywords: miRNA, WI-38, p53, GSE56, Senes...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-12450 | biostudies-arrayexpress
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