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ProteomicsIdentification and monitoring of host cell proteins by mass spectrometry combined with high performance immunochemistry testing
Biotherapeutics are often produced in non-human host cells like Escherichia coli, yeast, and various mammalian cell lines. A major focus of any therapeutic protein purification process is to reduce host cell proteins to an acceptable low level. In this study, various E. coli host cell proteins were ...
ORGANISM(S): Escherichia coli 
2014-04-15 | PXD000509 | Pride
Host cell protein  protein purification  mass spectrometry  affinity enrichment chromatography  cobas  high throughput immunochemistry testing 
TranscriptomicsPustular psoriasis: molecular pathways and effects of spesolimab in generalized pustular psoriasis
pre- and post spesolimab treatment gene expression analysis of blood as well as skin biopsy samples.
ORGANISM(S): Homo sapiens 
2023-06-04 | E-MTAB-11144 | biostudies-arrayexpress
UnknownTreatment Adherence and Its Impact on Disease-Free Survival in the Breast International Group 1-98 Trial of Tamoxifen and Letrozole, Alone and in Sequence.
Not available
S-EPMC4962733 | biostudies-literature
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
UnknownSpecifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.
Not available
S-EPMC5244667 | biostudies-literature
UnknownPlasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer: the STAMPEDE Phase 3 Randomized Clinical Trial.
Not available
S-EPMC11869088 | biostudies-literature
UnknownEfficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
Not available
S-EPMC5731244 | biostudies-literature
UnknownInsulin degludec improves glycaemic control with lower nocturnal hypoglycaemia risk than insulin glargine in basal-bolus treatment with mealtime insulin aspart in Type 1 diabetes (BEGIN(®) Basal-Bolus Type 1): 2-year results of a randomized clinical trial.
Not available
S-EPMC4264937 | biostudies-literature
UnknownPreoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin-angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial.
Not available
S-EPMC11103084 | biostudies-literature
UnknownHLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Not available
S-EPMC4702958 | biostudies-literature
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