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TranscriptomicsA Common Docking (CD) Domain in Progesterone Receptor-B Links MKP3-Dependent Rapid Signaling Events to JAK/STAT Regulation of Gene Expression Required for Breast Cancer Cell Proliferation
Progesterone receptors (PRs) are critical context-dependent transcription factors required for normal uterine (PR-A) and mammary gland (PR-B) development. Progesterone is proliferative in the breast, where PR-target genes include paracrine factors that mediate mammary stem cell self-renewal. In the ...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-46850 | biostudies-arrayexpress
Proteomicsphospho HMMR Co-Immunoprecipitation
Phosphorylated HMMR was immunoprecipitated from syncronized M or G2 phase HELA cells to identify interacting proteins specific to the phosphorylated HMMR form.
ORGANISM(S): Homo sapiens (Human) 
2017-10-09 | PXD007897 | Pride
Interaction Ppi Hmmr Phosphorylation 
UnknownPathogenic variants in the cohesin loader subunit MAU2 lead to a new Cornelia de Lange Syndrome subtype.
Not available
S-EPMC12668068 | biostudies-literature
TranscriptomicsProstate CancerM-bM-^@M-^SAssociated Gene Expression Alterations Determined from Needle Biopsies
To accurately identify gene expression alterations that differentiate neoplastic from normal prostate epithelium using an approach that avoids contamination by unwanted cellular components and is not compromised by acute gene expression changes associated with tumor devascularization and resulting i...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-40373 | biostudies-arrayexpress
UnknownProximal Distance Algorithms: Theory and Practice.
Not available
S-EPMC6812563 | biostudies-literature
UnknownLoss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.
Not available
S-EPMC4014191 | biostudies-literature
TranscriptomicsDifferential analysis between Rev3l KO and Rev3l WT mouse embryonic fibroblast
DNA polymerase zeta (Polz) plays a key role in translesion DNA synthesis. Inactivation of the gene encoding its catalytic subunit (Rev3L) leads to embryonic lethality and abrogates cell proliferation in primary fibroblasts highlighting an essential role of Polz in mammalian cells. However, its biol...
ORGANISM(S): Mus musculus 
2021-08-19 | E-MTAB-8338 | biostudies-arrayexpress
TranscriptomicsIpsA, a novel transcriptional regulator required for inositol derived lipid formation in Corynebacteria and Mycobacteria
The development of new drugs against tuberculosis and diphtheria is focused on disrupting the biogenesis of the cell wall, the unique architecture of which confers resistance against current therapies. The enzymatic pathways involved in the synthesis of the cell wall by these pathogens are well unde...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2014-01-13 | E-GEOD-50210 | biostudies-arrayexpress
UnknownPotentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.
Not available
S-EPMC3533467 | biostudies-literature
TranscriptomicsGut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
Acetate, propionate and butyrate are the main short-chain fatty acids (SCFAs) that arise from the fermentation of fibers by the colonic microbiota. While many studies focus on the regulatory role of SCFAs, their quantitative role as a catabolic or anabolic substrate for the host has received relativ...
ORGANISM(S): Mus musculus 
2013-10-21 | E-GEOD-45926 | biostudies-arrayexpress
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