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TranscriptomicsExpression profile of zebrafish embryonal rhabdomyosarcoma
Fluorescent-labeled zebrafish RAS-induced embryonal rhabdomyosarcoma (ERMS) were created to facilitate in vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in diverse cellular compartments. Using this strategy, we have identified a molecularly distinc...
ORGANISM(S): Danio rerio 
2012-12-01 | E-GEOD-32425 | biostudies-arrayexpress
TranscriptomicsDiscrete subsets of myogenic and mesenchymal precursors give rise to soft tissue sarcomas of distinct lineage differentiation
This work examines sarcoma formation within discrete subsets of KRAS(G12V)-expressing p16p19null myogenic and mesenchymal cells found normally in skeletal muscle. We show that prospectively isolated skeletal muscle precursor cells (SMPs) within the satellite cell pool can serve as cancer cells-of-or...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-22841 | biostudies-arrayexpress
TranscriptomicsEvolution of monoclonal zebrafish Myc-induced T-ALL, assessed by copy number variant analysis
Clonal evolution and intratumoral heterogeneity drive cancer progression through unknown molecular mechanisms. To address this issue, functional differences between single T-cell acute lymphoblastic leukemia (T-ALL) clones were assessed using a zebrafish transgenic model. Functional variation was ob...
ORGANISM(S): Danio rerio 
2014-01-29 | E-GEOD-54482 | biostudies-arrayexpress
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