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ProteomicsGAIN domain cleavage of aGPCRs requires multiple domain-extrinsic factors coordinated by the 7TM region
The G protein-coupled receptor (GPCR) autoproteolysis-inducing (GAIN) domain is a structurally conserved and tell-tale fold of class B2/adhesion GPCRs (aGPCRs). Self-cleavage of the GAIN domain is central for mechanobiological and signaling properties of aGPCRs. Biochemical analyses and atomistic de...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD056561 | Pride
Adhesion gpcr Photo-crosslinking Gain domain 
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