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TranscriptomicsTranscription profiling of mouse microglia reveals luteolin has anti-inflammatory and neurotrophic effects on microglia
Our aim was to identify genes that were differentially expressed in microglia stimulated with Lipopolysaccharide, Luteolin, or both. Affymetrix microarrays were used to analyze RNA samples Experiment Overall Design: RNA from control BV-2 cells, and cells treated for 24h with LPS, Luteolin, or LPS+Lu...
ORGANISM(S): Mus musculus 
2010-01-23 | E-GEOD-18740 | biostudies-arrayexpress
TranscriptomicsIdentification of PU.1 target genes by expression profiling of PUER cells
PU.1 is a key transcription factor for macrophage differentiation. Novel PU.1 target genes were identified by mRNA profiling of PU.1-deficient progenitor cells (PUER) before and after PU.1 activation. We used two different types of Affymetrix DNA-microarrays (430 2.0 arrays and ST 1.0 exon arrays) t...
ORGANISM(S): Mus musculus 
2008-10-11 | E-GEOD-13125 | biostudies-arrayexpress
GenomicsDeciphering the cis-regulatory architecture of mammalian photoreceptors
In order to define the genomic targets of Crx, we carried out Crx chromatin-immunoprecipitation followed by massively parallel sequencing (ChIP-seq) of eight-week-old mouse retinas using the Solexa platform. Sequence reads were mapped to the genome and 'peaks' were identified. These data were subje...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-20012 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ileum and colonic tissues from patients with Crohns disease or ulcerative colitis
Samples for microarray analysis were derived from terminal ileum and colonic tissues from probands with Crohn's disease and Ulcerative Colitis and control patients, respectively. IBD tissue biopsies from non-inflamed regions 10 cm distant from pathological areas were selected. To minimize inter-indi...
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1152 | biostudies-arrayexpress
TranscriptomicsTranscriptomic definition of curcumin treated microglia
Curcumin is a potent modulator of the inflammatory transcriptome in microglia We have performed global gene expression analysis of BV-2 microglial cells under the following conditions: untreated, 20 µM Curcumin-treated, 100ng/ml LPS-treated, or 20 µM Curcumin-treated + 100ng/ml LPS-treated
ORGANISM(S): Mus musculus 
2010-09-29 | E-GEOD-23639 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of retinae from wildtype and retinoschisin knockout mice (Rs1h-/Y) at postnatal day 7 to understand the effect of retinoschisin on gene expression
Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Experiment Overall Design: RNAs from retinae from 3 Wildtype Mice versus 3 Retinoschisin-KO mice (Rs1h-/Y) at postnatal day 7 (P7) were hybridized onto Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5581 | biostudies-arrayexpress
UnknownInhibition of DYRK1B BY C81 impedes inflammatory processes in leukocytes by reducing STAT3 activity.
Not available
S-EPMC11846820 | biostudies-literature
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
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