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ProteomicsPeritoneal Macrophages are a Centralized Immune Hub Regulating Distal Healing by the Release of Plasma Fibronectin
The peritoneal cavity contains a large population of GATA6-expressing large peritoneal macrophages (LPMs), known to support healing of intra-abdominal organs. In this study, we aimed to explore their full sphere of influence by examining their ability to perform wound healing at distant sites outsid...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-12 | PXD066819 | Pride
Large peritoneal macrophages Wound healing 
TranscriptomicsTemporal gene expression profiling of myeloid cells during the peritoneal foreign body response
This study dermined the temporal gene expression profile of myeloid subpopulations recruited to the peritoneal cavity to encapsulate implanted foreign material. Sterile foreign objects were inserted into the peritoneal cavities of MacGreen mice (in which the Csf1r promoter directs myeloid-specific ...
ORGANISM(S): Mus musculus 
2014-09-17 | E-GEOD-53101 | biostudies-arrayexpress
ProteomicsProteome profiling of PMJ2-R and primary peritoneal macrophages
In vitro models are often used to study the functions of macrophages, including the process of phagocytosis. The use of primary macrophages has limitations associated with the individual characteristics of animals, which can lead to insufficient standardization of the results obtained. This disadvan...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-12 | PXD022133 | Pride
Peritoneal macrophages Phagocytosis Pmj2-r Proteome Lc-ms/ms 
TranscriptomicsCompare RNA profile between LPS+CPN and LPS+CPN+GGOH treated peritoneal macrophages
To find out genes regulated by geranylgeraniol (GGOH) treatment in peritoneal macrophage, we compared gene expression of cells treated with 200ng ml LPS and 250 micromolar compactin versus 200ng ml LPS, 250 micromolar compactin and 100micromolar GGOH. To find out upregulated or downregulated genes r...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-48646 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine macrophages after infection with Paracoccidioides brasiliensis
Identification of transcripts in mouse peritoneal macrophages infected by P. brasiliensis yeasts cells
ORGANISM(S): Mus musculus 
2007-08-31 | E-MEXP-1093 | biostudies-arrayexpress
TranscriptomicsPeritoneal and testicular macrophage mrna expression after exposure to UPEC CFT073
Ascending bacterial infections of the male genitourinary tract by Escherichia coli are an important cause of male infertility. Thus understanding mechanisms by which immunocompetent cells such as testicular macrophages (TM) respond to infection and how bacterial pathogens manipulate defense pathways...
ORGANISM(S): Rattus norvegicus 
2010-10-20 | E-GEOD-24780 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS)
Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing inter-species differences in the transcriptional responses of primary human and mouse macrophages to the TLR4 agon...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19490 | biostudies-arrayexpress
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
TranscriptomicsConservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
This SuperSeries is composed of the following subset Series: GSE19482: Transcriptional responses of human monocyte-derived macrophages (HMDM) to lipopolysaccharide (LPS) GSE19490: Transcriptional responses of mouse BMM and TEPM to lipopolysaccharide (LPS) GSE19765: Transcriptional responses of human...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-19492 | biostudies-arrayexpress
GenomicsTIM4 enables large peritoneal macrophages to cross-present tumor antigens at early stages of tumorigenesis
TIM4 enables large peritoneal macrophages to cross-present tumor antigens at early stages of tumorigenesis
PRJNA1015688 | ENA
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