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TranscriptomicsLetrozole (Femara) early and late responses to treatment
In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of th...
ORGANISM(S): Homo sapiens 
2010-07-28 | E-GEOD-20181 | biostudies-arrayexpress
GenomicsGenomic study of an AT-AML
Ataxia Telangiectasia (A-T) is caused by biallelic mutations in ATM and confers predisposition to cancer, with acute myeloid leukaemia (AML) being rarely observed. We investigated an AML arising in an A-T patient for secondary genetic events by performing whole exome sequencing of serial samples ove...
EGAS00001004392 | EGA
Genomics98be40b5-5141-4ceb-8723-6ddc59a9cda6 - samples
Serial samples from one AT-AML patient as described in publication Goldgraben et al Pediatric Blood & Cancer 2020. Whole exome sequencing of a AT-'germline' blood sample, one bone marrow sample (at AML diagnosis) and 3 AML blood samples. Library preped using the Illumina Nextera Rapid Capture Exom...
EGAD00001006090 | EGA
GenomicsInherited Predisposition to Cancer Projects Data Access Committee
Data Access Committee EGAC00001001565
EGAC00001001565 | EGA
TranscriptomicsTranscription profiling of human sequential breast cancer biopsies during letrozole treatment
In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of th...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5462 | biostudies-arrayexpress
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