Sort   by:  
 Page size 
GenomicsCancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex
ASXL1 is the obligate regulatory subunit of a deubiquitinase complex whose catalytic subunit is BAP1. Heterozygous mutations of ASXL1 that result in premature truncations are frequent in myeloid leukemias and Bohring-Opitz syndrome. Here, we demonstrate that truncated ASXL1 proteins confer enhanced ...
ORGANISM(S): Mus musculus 
2015-03-11 | E-GEOD-65555 | biostudies-arrayexpress
ModelsAho2010_RefRec_S_cerevisiae
This model is described in the article: Reconstruction and Validation of RefRec: A Global Model for the Yeast Molecular Interaction Network Aho T, Almusa H, Matilainen J, Larjo A, Ruusuvuori P, Aho K-L, Wilhelm T, Lähdesmäki H, Beyer A, Harju M, Chowdhury S, Lei...
2005-01-01 | MODEL3883569319 | BioModels
TranscriptomicsIdentification of global regulators of T-helper cell lineage specification (BeadChip)
The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarising conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-71575 | biostudies-arrayexpress
TranscriptomicsIdentification of global regulators of T-helper cell lineage specification (RNA-Seq)
The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarizing conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-71645 | biostudies-arrayexpress
GenomicsOverexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer
Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-48308 | biostudies-arrayexpress
TranscriptomicsAn integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation
The aim of this dataset was to study in detail the transcription kinetics initiated by cytokines IL-12 and IL-4 in early differentiation of Th1 and Th2 cells, respectively. Total RNA obtained from activated and IL-12 or IL-4 & anti-IL-12 treated cord blood CD4+ T cells, 12, 24, 48, and 72 hours afte...
ORGANISM(S): Homo sapiens 
2012-11-09 | E-GEOD-32959 | biostudies-arrayexpress
Sort   by:  
 Page size