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ProteomicsInvestigation of LARP1 regulated cellular pathways in acute myeloid leukemia
La-related protein 1 (LARP1) is an RNA-binding protein and downstream effector of mTOR and CDK9 signaling that regulates the translation of 5’-TOP mRNAs. While elevated LARP1 expression has been linked to poor prognosis in acute myeloid leukemia (AML), its mechanistic role remains unclear. Using CRI...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD064460 | Pride
Larp1 Acute myeloid leukemia 
TranscriptomicsLARP1 mRNP scaffolds mTORC1 to stimulate translation initiation of an essential class of mRNAs
The RNA biding protein, LARP1, has been proposed to function downstream of mTORC1 to positively regulate the translation of 5M-bM-^@M-^YTOP mRNAs such as ribosome protein (RP) mRNAs. However, its regulatory roles in mTORC1-mediated translation remain unclear. PAR-CLIP of LARP1 revealed its direct an...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-59599 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of WT and larp1 mutant 21 days old seedling at 20°C or following a heat stress (15 min at 38°C)
We report the identification of a heat-stress mediated mRNA decay in arabidopsis that is mediated by the XRN4 exonuclease and LARP1 RNA-binding protein. mRNA population in WT and larp1 mutant at 20C or 15 min at 38C
ORGANISM(S): Arabidopsis thaliana 
2014-03-28 | E-GEOD-51879 | biostudies-arrayexpress
ProteomicsGlobal analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis
In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding proteins (RBPs) are a large class of post-transcriptional regulators that have been increasingly implicated in carcinogenesis. By integrating mul...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD030215 | Pride
Post-transcriptional regulation Larp1 Myc Rna-binding protein Cancer 
GenomicsGCN2 suppresses TOP mRNA translation via LARP1
GCN2 suppresses TOP mRNA translation via LARP1
PRJNA701320 | ENA
GenomicsDistinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs [LARP1]
Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAs [LARP1]
PRJNA975193 | ENA
ProteomicsMYC as a Key Regulator of Protein Synthesis: Characterization of Downstream Targets in Multiple Myeloma
Multiple myeloma (MM) is a malignant plasma cell disorder and frequently characterized by the 16 dysregulation of the MYC oncogene, which is associated with poor prognosis and disease progression. While MYC's involvement in transcriptional regulation is well-established, the functional role of MYC t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-15 | MSV000092169 | MassIVE
GenomicsIdentification of LARP1 targets in naive CD4 T cells [eCLIP]
Identification of LARP1 targets in naive CD4 T cells [eCLIP]
PRJNA672953 | ENA
GenomicsInvestigation of LARP1 regulated cellular pathways in acute myeloid leukemia
Investigation of LARP1 regulated cellular pathways in acute myeloid leukemia
PRJNA1300482 | ENA
GenomicsmTOR- and LARP1-dependent regulation of TOP mRNA poly(A) tail and ribosome loading [LARP1 KD, Torin1]
mTOR- and LARP1-dependent regulation of TOP mRNA poly(A) tail and ribosome loading [LARP1 KD, Torin1]
PRJNA573100 | ENA
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