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ProteomicsIntroducing a new type of organotypic laryngeal mucosa model
Research of human vocal fold (VF) biology is hampered by several factors. The sensitive microstructure of the VF mucosa is one of them and limits the in vivo research, as biopsies carry the unbearable risk of scarring. A laryngeal organotypic model consisting of VF epithelial cells and VF fibroblast...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD033688 | Pride
In vitro Proteomics Oral buccal mucosa Laryngeal mucosa model Vocal folds 
UnknownIntroducing a new type of alternative laryngeal mucosa model.
Not available
S-EPMC10313048 | biostudies-literature
GenomicsOral mucosa organoids as a potential model for personalized therapies
Organoids were established from both tumor and matched wildtype tissue from patients diagnosed with head and neck squamous cell carcinoma (HNSCC). In order to confirm tumor status and identify oncogenic driver mutations, DNA derived of these organoids was sequenced. After validation of tumor identit...
EGAS00001003628 | EGA
UnknownTissue-Engineered Implant for Hemilaryngectomy Reconstruction with Recurrent Laryngeal Nerve Injury.
Not available
S-EPMC11529076 | biostudies-literature
GenomicsTumor-specific expression of let-7i and miR-192 is associated with resistance to cisplatin-based chemoradiotherapy in patients with larynx and hypopharynx cancer
Background: The majority of patients with locally advanced larynx or hypopharynx squamous cell carcinoma are treated with organ preserving chemoradiotherapy (CRT). Clinical outcome following CRT varies greatly. We hypothesized tumor microRNA (miRNA) expression is predictive for outcome following CRT...
EGAS00001004001 | EGA
TranscriptomicsIdentification of GNG7 as An Epigenetically Silenced Gene in Head and Neck Cancer by Gene Expression Profiling
Silencing of tumor suppressor genes plays a vital role in head and neck carcinogenesis. Aberrant hypermethylation in the promoter region of some known or putative tumor suppressor genes (TSGs) occurs frequently during the development of various cancers including head and neck squamous cell carcinoma...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-29330 | biostudies-arrayexpress
UnknownOptimized Generation of Primary Human Epithelial Cells from Larynx and Hypopharynx: A Site-Specific Epithelial Model for Reflux Research.
Not available
S-EPMC7103601 | biostudies-literature
UnknownDrainage of amniotic fluid delays vocal fold separation and induces load-related vocal fold mucosa remodeling.
Not available
S-EPMC7494656 | biostudies-literature
UnknownEffect of Ligament Fibers on Dynamics of Synthetic, Self-Oscillating Vocal Folds in a Biomimetic Larynx Model.
Not available
S-EPMC10604794 | biostudies-literature
TranscriptomicsNID2 and HOXA9 promoter hypermethylation as biomarkers to prevent and detect Oral Cavity Squamous Cell Carcinoma
Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadCh...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-28217 | biostudies-arrayexpress
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