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TranscriptomicsIdentification of miRNAs which bind to YB-1 protein
To assess the direct association of the nucleic acid binding protein yb-1 with mature microRNAs in breast cancer. To do this we performed immunoprecipitation (IP) of YB-1 protein to pull-down linked RNAs Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-50141 | biostudies-arrayexpress
TranscriptomicsEffects of YB-1 protein reduction on microRNA abundance in breast cancer cell-lines
To assess the association of the nucleic acid binding protein yb-1 with mature microRNAs levels in breast cancer. To do this we performed YB-1 siRNA treatement in triplicates alongside an siRNA control Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used, ...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-50087 | biostudies-arrayexpress
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
TranscriptomicsThe effects of YB1 knockdown on global gene expression in tumour cell lines.
Y-box binding factor 1 (YB1) has been associated with prognosis in many tumor types. Reduction of YB-1 inhibits tumor cell growth in vitro and in vivo Total RNA was isolated from A549, MCF7 and HCT116 tumor cell lines following 48hr treatment with 5nM Yb1 siRNA
ORGANISM(S): Homo sapiens 
2011-11-30 | E-GEOD-28433 | biostudies-arrayexpress
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