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TranscriptomicsConcerted action of Helios and Ikaros balances the strength of B cell receptor signaling and controls the expression of inositol 5-phosphatase SHIP
Inositol 5-phosphatase SHIP is differentially expressed in Ikaros and Helios deficient cells. In the absense of Ikaros SHIP is upregulated where as in the absense of Helios it is downregulated. Ikaros binds to the promoter of the SHIP gene. Article provides insight into the mechanisms of action Ikar...
ORGANISM(S): Gallus gallus 
2010-07-19 | E-GEOD-20946 | biostudies-arrayexpress
TranscriptomicsCross-species meta-analysis of regulatory networks of the Pax5 transcription factor
Transcription profiling of chicken Pax5 deficient DT40 B cell line to investigate the targets of Pax5 which is required for B-cell differentiation Used in cross-species comparison to investigate evolutionarily conserved regulatory circuits in B cell development Pax5 deficient DT40 B cells (3 biologi...
ORGANISM(S): Gallus gallus 
2013-12-31 | E-GEOD-34687 | biostudies-arrayexpress
no omics definedTranscription profiling of human osteoclasts, dendritic cells, macrophages and endothelial cells derived from CD14+ peripheral blood mononuclear cells
An experiment was performed to compare the gene expression of human osteoclasts, dendritic cells, macrophages and endothelial cells derived from CD14+ PBMCs.
ORGANISM(S): Homo sapiens 
2007-02-24 | E-MEXP-916 | biostudies-arrayexpress
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