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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
GenomicsHERV-K HML2
HERV-K HML-2 integration sites in NCCITs
PRJEB15674 | ENA
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
ProteomicsIdentification of PP1c-PPP1R12A Substrates Using K-BIPS (Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates)
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) interacts with the catalytic subunit of protein phosphatase 1 (PP1c) to form one of the many protein phosphatase 1 complexes, PP1c-PPP1R12A (or myosin phosphatase). In addition to a well-documented role in muscle contraction, the PP1c-PPP1R12A ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD035213 | Pride
Protein phosphatase 1  pp1  ppp1r12a  chemoproteomics  substrate identification 
ProteomicsIdentification of PP1c-PPP1R12A Substrates Using K-BIPS (Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates)
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) interacts with the catalytic subunit of protein phosphatase 1 (PP1c) to form one of the many protein phosphatase 1 complexes, PP1c-PPP1R12A (or myosin phosphatase). In addition to a well-documented role in muscle contraction, the PP1c-PPP1R12A ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD035212 | Pride
Protein phosphatase 1  pp1  ppp1r12a  chemoproteomics  substrate identification 
ProteomicsIdentification of PP1c-PPP1R12A Substrates Using K-BIPS (Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates)
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) interacts with the catalytic subunit of protein phosphatase 1 (PP1c) to form one of the many protein phosphatase 1 complexes, PP1c-PPP1R12A (or myosin phosphatase). In addition to a well-documented role in muscle contraction, the PP1c-PPP1R12A ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD035211 | Pride
Protein phosphatase 1  pp1  ppp1r12a  chemoproteomics  substrate identification 
GenomicsRNAseq transcriptome analysis of K. pneumoniae MS6671 with PBT2 and colistin
RNAseq transcriptome analysis of K. pneumoniae MS6671 with PBT2 and colistin
PRJNA643224 | ENA
TranscriptomicsRNAseq transcriptome analysis of K. pneumoniae MS6671 with PBT2 and colistin
The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum -lactamase (ESBL)-producing bacteria is a critical threat to human health, and new treatment strategies are urgently required. Here, we investigated the ability of the safe-for-human use ionophore PBT2 to restore an...
ORGANISM(S): Klebsiella pneumoniae 
2020-07-01 | GSE153553 | GEO
TranscriptomicsRNAseq transcriptome analysis of K. pneumoniae MS6671 and E. coli MS8345 treated with PBT2
The emergence of colistin resistance in carbapenem-resistant and extended-spectrum ß-lactamase (ESBL)-producing bacteria is a significant threat to human health, and new treatment strategies are urgently required. Here we investigated the ability of the safe-for-human use ionophore PBT2 to restore a...
ORGANISM(S): Escherichia coli Klebsiella pneumoniae 
2019-06-13 | GSE132637 | GEO
UnknownQuality of vitamin K antagonist treatment during the last year of life.
Not available
S-EPMC12087289 | biostudies-literature
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