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GenomicsGenome-wide binding of STAT3 and STAT5 under Th17 conditions (ChIP-Seq)
Interleukin 2 (IL-2), a cytokine linked to human autoimmune diseases, limits IL-17 production. We show that deletion of Stat3 in T cells abrogates IL-17 production and attenuates autoimmunity associated with IL-2 deficiency. While STAT3 induces IL-17 and RORγt and inhibits Foxp3, IL-2 inhibited IL-1...
ORGANISM(S): Mus musculus 
2011-02-09 | E-GEOD-26552 | biostudies-arrayexpress
TranscriptomicsRegulation of microRNA Expression and Abundance during Lymphopoiesis
Although the cellular concentration of miRNAs is critical to their function, how miRNA expression and abundance are regulated during ontogeny is unclear. We used deep-sequencing to characterize the microRNome from most developing lymphocytes, various hematopoietic cell lineages, and representative m...
ORGANISM(S): Mus musculus 
2010-06-07 | E-GEOD-21630 | biostudies-arrayexpress
TranscriptomicsRoles of STAT3 and STAT5 in regulation of gene expression under Th17 differentiation
Interleukin 2 (IL-2), a cytokine linked to human autoimmune diseases, limits IL-17 production. We show that deletion of Stat3 in T cells abrogates IL-17 production and attenuates autoimmunity associated with IL-2 deficiency. While STAT3 induces IL-17 and ROR?t and inhibits Foxp3, IL-2 inhibited IL-1...
ORGANISM(S): Mus musculus 
2011-02-09 | E-GEOD-26551 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in human tonsillar B cell populations
small RNA profiles of 6 human tonsillar B cell populatios (naive B cells, pre-germinal center B cells, centrocytes, centroblasts, memory B cells, and plasma cells) were determined by deep sequencing. These samples were compared to mouse developing lymphocytes, various hematopoietic cell lineages, a...
ORGANISM(S): Homo sapiens 
2010-07-23 | E-GEOD-23090 | biostudies-arrayexpress
TranscriptomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1-4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argu...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23505 | biostudies-arrayexpress
TranscriptomicsA mouse model of HIES reveals pro and anti-inflammatory functions of STAT3
Mutations of STAT3 underlie the autosomal dominant form of hyper-immunoglobulin E syndrome (HIES). STAT3 has critical roles in immune cells and thus, hematopoietic stem cell transplantation (HSCT), might be a reasonable therapeutic strategy in this disease. However, STAT3 also has critical function...
ORGANISM(S): Mus musculus 
2014-03-06 | E-GEOD-55607 | biostudies-arrayexpress
TranscriptomicsDiverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis [Affymetrix Expression]
STAT3, an essential transcription factor with pleiotropic functions, plays critical roles in the pathogenesis of autoimmunity. Despite recent data linking STAT3 with inflammatory bowel disease, exactly how it contributes to chronic intestinal inflammation is not known. Using a T cell transfer model ...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21670 | biostudies-arrayexpress
TranscriptomicsInterleukin-27 priming of T cells controls Interleukin-17-production in trans via induction of Programmed cell death ligand 1
Interleukin (IL)-27 is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 might exert its immunosuppressive effect, we analyzed genes in T cells rapidly induced by IL-27. We found that IL-27 priming of naïve T cells upregu...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-38375 | biostudies-arrayexpress
GenomicsEnhanced Pathogenicity of Th17 cells Generated in the Absence of Transforming Growth Factor-β Signaling: ChIPSeq
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity. Crucial for T helper17 (Th17) cells in vivo, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and transforming growth factor (TGF)-β1 have been argued to ...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23681 | biostudies-arrayexpress
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