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ProteomicsDecoupling of mRNA and protein expression in aging brains reveals the age-dependent adaptation of specific gene subsets
During aging, changes in gene expression are associated with decline in physical and cognitive abilities. Here, we investigated the connection between changes of mRNA and protein expression in the brain by comparing the transcriptome and proteome of the mouse cortex during aging. Our transcriptomic ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD038179 | Pride
Proteomics Brain Cortex Mouse Aging Mrna 
UnknownRetinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology.
Not available
S-EPMC3406717 | biostudies-literature
UnknownSynthesis and Antimalarial Activities of New Hybrid Atokel Molecules.
Not available
S-EPMC9092290 | biostudies-literature
TranscriptomicsTranscription profiling of human primary hematopoietic CD34+ cells to investigate Growth Factor Independence-1B (Gfi-1B) functions
Growth Factor Independence-1B (Gfi-1B) is a transcriptional repressor essential for erythropoiesis and megakaryopoiesis. Targeted gene disruption of Gfi-1B in mice leads to embryonic lethality due to failure to produce definitive erythrocytes, hindering the study of Gfi-1B function in adult hematopo...
ORGANISM(S): Homo sapiens 
2010-04-19 | E-MEXP-2560 | biostudies-arrayexpress
ProteomicsNicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner
Nicotinamine riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust behavioral and cognitive benefits as well as effects alleviating neuroinflammation in AD mouse models. Gene expression studies hint benefitial induction of neuroprotective pathways for AD. However, the pr...
ORGANISM(S): Mus Musculus 
PXD053897 |
UnknownProspective Evaluation of Magnetic Resonance Imaging and [18F]Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography at Diagnosis and Before Maintenance Therapy in Symptomatic Patients With Multiple Myeloma Included in the IFM/DFCI 2009 Trial: Results of the IMAJEM Study.
Not available
S-EPMC5578392 | biostudies-literature
Unknown3D Imaging of Nanoparticle Distribution in Biological Tissue by Laser-Induced Breakdown Spectroscopy.
Not available
S-EPMC4951682 | biostudies-literature
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
TranscriptomicsThe LSD1/KDM1A neuro-specific isoform regulates neuronal differentiation through H3K9 demethylation [Affymetrix]
During brain development, histone-modifying enzymes play an important role by orchestrating transcriptional programs that regulate neuronal maturation. Lysine-Specific Demethylase 1 (LSD1, also named as KDM1A) functions as a transcriptional repressor by removing methyl groups at lysine 4 of histone ...
ORGANISM(S): Homo sapiens 
2015-06-05 | E-GEOD-63097 | biostudies-arrayexpress
TranscriptomicsExpression Data from Uveal Melanoma primary tumors.
A high percentage of uveal melanoma patients develop metastatic tumors that predominately occur in the liver. To identify genes associated with metastasis in this pathology, we studied 63 molecular profiles derived from gene expression microarrays performed from enuceated primary tumors. Metastasis ...
ORGANISM(S): Homo sapiens 
2010-12-14 | E-GEOD-22138 | biostudies-arrayexpress
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