BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...
This the model from the article:
Computer model of action potential of mouse ventricular myocytes.
Bondarenko VE, Szigeti GP, Bett GC, Kim SJ, Rasmusson RL Am. J. Physiol. Heart Circ. Physiol.
2004 Sep;287(3):H1378-403. Pubmed ID: 15142845
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BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...
