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MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
UnknownMajor Outcomes With Personalized Dialysate TEMPerature (MyTEMP): Rationale and Design of a Pragmatic, Registry-Based, Cluster Randomized Controlled Trial.
Not available
S-EPMC7003172 | biostudies-literature
UnknownGenomic loci susceptible to systematic sequencing bias in clinical whole genomes.
Not available
S-EPMC7111519 | biostudies-literature
UnknownThe successes and challenges of harmonising juvenile idiopathic arthritis (JIA) datasets to create a large-scale JIA data resource.
Not available
S-EPMC10339614 | biostudies-literature
UnknownFunctional genomics provide key insights to improve the diagnostic yield of hereditary ataxia.
Not available
S-EPMC10316781 | biostudies-literature
UnknownWhole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study.
Not available
S-EPMC8850201 | biostudies-literature
TranscriptomicsPancreatic Gene Expression from Wild-Type, Stat1-Transgenic, and Stat1-CC-Transgenic Mice
Pancreatic Gene Expression from Wild-Type, Stat1-Transgenic, and Stat1-CC-Transgenic Mice. This data was part of the set of data utilized to identify PARP9/DTX3L as a novel antiviral gene. Keywords: transgene state analysis RNA was extracted from the pancreas of 3 mice per genotype (wild-type, Stat1...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-61414 | biostudies-arrayexpress
TranscriptomicsEffects of Active or Inactive PARP9/DTX3L Overexpression on ISG Expression
U3A cells expressing Stat1 were transfected with either wild-type PARP9 and DTX3L, or inactive mutants of PARP9 and DTX3L. Stable lines were assessed for gene expression to identify effects of PARP9/DTX3L overexpression on ISG expression. Keywords: interferon, PARP9, DTX3L, antiviral RNA was isolate...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-61411 | biostudies-arrayexpress
TranscriptomicsModified Stat1 Confers Enhanced Interferon Responsiveness and Improved Baseline Antiviral Host Defense
U3A cells stably expressing wild-type STAT1 or STAT1-CC were treated with interferon beta (10U/ml) or control for 24 hours to assess effects of stat1 modifications, interferon, and the interaction on gene expression. Keywords: interferon, STAT1, STAT1-CC, STAT1CC, STAT-1C, antiviral RNA was isolated...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-61413 | biostudies-arrayexpress
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