Sort   by:  
 Page size 
TranscriptomicsAscl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state
Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopically in heterologous cells. Herein, we screened the key molecular factors governing the dopaminergic neuronal specification during brain development fo...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-27174 | biostudies-arrayexpress
TranscriptomicsInactivation of the exosome ribonuclease DIS3 triggers the pluripotency factor LIN28B, repressing let-7 miRNAs and unleashing MYC and RAS.
Somatic mutations affecting DIS3, the catalytic component of the RNA exosome, have been found in up to 18% of patients affected by the hematological cancer multiple myeloma. Here we show that DIS3 targets and degrades the pluripotency factor LIN28B. In cancer cells, DIS3 inactivation leads to enhanc...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-55246 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiles of CRC-derived samples by scGET-seq
Multiple samples of Patient Derived Xenografts (PDX) of a EGFR-resistant colorectal cancer are recovered at different times and profiled by scGET-seq.
ORGANISM(S): Homo sapiens 
2021-08-17 | E-MTAB-9659 | biostudies-arrayexpress
TranscriptomicsscGET-seq profile of NIH-3T3 cells with Kdm5c knockdown
scGET-seq profiling of NIH3T3 cells in which Kdm5c was silenced with antisense shRNA or with a control scramble shRNA.
ORGANISM(S): Mus musculus 
2021-08-17 | E-MTAB-9651 | biostudies-arrayexpress
TranscriptomicsSingle cell profiling of a Caki-1:HeLa cell mixture by scATAC-seq and scGET-seq
A mixture of Caki-1 and HeLa cells in known proportions (80:20) is profiled using 10x Chromium scATAC-seq or scGET-seq protocols.
ORGANISM(S): Homo sapiens 
2021-08-17 | E-MTAB-9650 | biostudies-arrayexpress
GenomicsLoss of histone demethylase JARID1C triggers genomic instability in cancer.
Chromatin remodelers are recurrently mutated in cancer. Among these, JARID1C, (KDM5C) a histone demethylase, is frequently inactivated in clear cell renal cell carcinoma (ccRCC) patients. How the genetic inactivation of JARID1C leads to cancer remains largely unknown. Here we report that JARID1C bin...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-73267 | biostudies-arrayexpress
TranscriptomicsscGET-seq profile of patient derived organoids
Two patient-derived organoids from liver metastasis of CRC samples were profiled by scGET-seq to analyze their genomic composition
ORGANISM(S): Homo sapiens 
2021-08-17 | E-MTAB-10219 | biostudies-arrayexpress
TranscriptomicsEpigenetic profile of iPSC differentiation process by scGET-seq
Induced pluripotent stem cells (iPSC) derived from fibroblasts of two healthy individuals were differentiated into NPC. Cells were profiled by scGET-seq.
ORGANISM(S): Homo sapiens 
2021-08-17 | E-MTAB-9649 | biostudies-arrayexpress
TranscriptomicsEpigenetic profile of iPSC differentiation process by scGET-seq
Induced pluripotent stem cells (iPSC) derived from fibroblasts of two healthy individuals were differentiated into NPC. Cells were profiled by scGET-seq.
ORGANISM(S): Homo sapiens 
2021-08-17 | E-MTAB-10218 | biostudies-arrayexpress
TranscriptomicsWhole genome transcriptional analysis of monocytes/macrophages purified from bone marrow of xeno-transplanted mice
The development and progression of CLL are dependent upon a complex microenvironmental network of cellular and molecular signals. As an example the in vitro survival of CLL cells is supported by nurse-like cells, which have been identified as a CLL-specific tumor-associated macrophage (TAM) populati...
ORGANISM(S): Mus musculus 
2016-02-16 | E-GEOD-57785 | biostudies-arrayexpress
Sort   by:  
 Page size