Sort   by:  
 Page size 
ProteomicsLck phosphorylation status of Lck Tyr192 and Tyr192/Tyr505 mutantsLck phosphorylation status of Lck Tyr192 and Tyr192/Tyr505 mutants
Lymphocyte-specific protein tyrosine kinase (Lck) is crucial for signaling from the T cell receptor (TCR) and is controlled through tyrosine phosphorylations. Phosphorylated Tyr505 (pTyr505) promotes a closed, inactive conformation of Lck, while pTyr394 is critical for kinase activity. Additionally,...
ORGANISM(S): Homo sapiens (Human) 
2021-04-02 | PXD014470 | Pride
T-cells Tyrosine phosphorylation Lck y505f Immunoprecipitation Jurkat-tag cells Lck kinase Lck y192e T cell receptor signalling Lck y192f 
TranscriptomicsGene expression profiles at single cell level of nucleotides optimized WT or S449A PTPN22 in J.Lck WT or J.Lck Y192F Jurkat cells
Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is encoded by a major autoimmunity gene and is a known inhibitor of T cell receptor (TCR) signaling. PTPN22 Ser449 is a novel phosphorylation site. Here we used optimized coding sequences (CDS) of PTPN22 WT or S449A eukaryotic expression vec...
ORGANISM(S): Homo sapiens 
2025-04-25 | GSE265961 | GEO
GenomicsGene expression profiles at single cell level of nucleotides optimized WT or S449A PTPN22 in J.Lck WT or J.Lck Y192F Jurkat cells
Gene expression profiles at single cell level of nucleotides optimized WT or S449A PTPN22 in J.Lck WT or J.Lck Y192F Jurkat cells
PRJNA1105053 | ENA
Sort   by:  
 Page size