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ProteomicsLck phosphorylation status of Lck Tyr192 and Tyr192/Tyr505 mutantsLck phosphorylation status of Lck Tyr192 and Tyr192/Tyr505 mutants
Lymphocyte-specific protein tyrosine kinase (Lck) is crucial for signaling from the T cell receptor (TCR) and is controlled through tyrosine phosphorylations. Phosphorylated Tyr505 (pTyr505) promotes a closed, inactive conformation of Lck, while pTyr394 is critical for kinase activity. Additionally,...
ORGANISM(S): Homo sapiens (Human) 
2021-04-02 | PXD014470 | Pride
T-cells Tyrosine phosphorylation Lck y505f Immunoprecipitation Jurkat-tag cells Lck kinase Lck y192e T cell receptor signalling Lck y192f 
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