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ProteomicsA novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1
High-throughput phenotype-based screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets and mechanisms of action. Here we show that a comp...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD027228 | Pride
Lung cancer Thermal proteome profiling Lcs3-sensitive luad cells 
GenomicsResponse of LUAD cells to LCS3
Response of LUAD cells to LCS3
PRJNA738470 | ENA
TranscriptomicsResponse of LUAD cells to LCS3
High-throughput phenotype-based screening of large libraries of compounds can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets and mechanisms of action. Here we show that a compound termed lung cancer scre...
ORGANISM(S): Homo sapiens 
2022-03-02 | GSE178311 | GEO
ProteomicsA novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1
Phenotype-based screening can identify unique small molecules that elicit a desired cellular response, but additional approaches are required to characterize their targets and mechanisms of action. Here we show that a compound termed LCS3, which selectively impairs the growth of human lung adenocarc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030294 | Pride
Lcs3 Thermal proteome profiling 
UnknownCharacterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells.
Not available
S-EPMC8904132 | biostudies-literature
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