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UnknownHedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification.
Parathyroid hormone-related protein (PTHrP) and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is unknown. Better understanding their involvement may provide therapeu...
S-EPMC6920702 | biostudies-literature
UnknownA Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.

Objective

To examine the genetic architecture of cam morphology using alpha angle (AA) as a proxy measure and conduct an AA genome-wide association study (GWAS) followed by Mendelian randomization (MR) to evaluate its causal relationship with hip osteoarthritis (OA).

Methods

Observati...
S-EPMC10374163 | biostudies-literature
UnknownNeurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial.

Objective

This study evaluates the 24-month follow-up for the NICHD Neonatal Research Network (NRN) Inositol for Retinopathy Trial.

Study design

Bayley Scales of Infants Development-III and a standardized neurosensory examination were performed in infants enrolled in the main trial. M...
S-EPMC8349854 | biostudies-literature
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