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UnknownSOX9 has distinct roles in the formation and progression of different non-small cell lung cancer histotypes.
The transcription factor SOX9 is a key regulator of multiple developmental processes and is frequently re-expressed in non-small cell lung cancer (NSCLC). Its precise role in the progression of NSCLC histotypes has, however, remained elusive. We show that SOX9 expression relates to poor overall surv...
S-EPMC11497254 | biostudies-literature
TranscriptomicsCharacterisation of microRNA expression in post-natal mouse mammary gland development [gene]
Background: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the breast epithelium. Our aim was to analyse these regulatory functions by deriving a comprehensive tissue-specific combined...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15054 | biostudies-arrayexpress
TranscriptomicsCharacterisation of microRNA expression in post-natal mouse mammary gland development
Background: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the breast epithelium. Our aim was to analyse these regulatory functions by deriving a comprehensive tissue-specific combined...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15057 | biostudies-arrayexpress
TranscriptomicsCharacterisation of microRNA expression in post-natal mouse mammary gland development [miRNA]
Background: The differential expression pattern of microRNAs (miRNAs) during mammary gland development might provide insights into their role in regulating the homeostasis of the breast epithelium. Our aim was to analyse these regulatory functions by deriving a comprehensive tissue-specific combined...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-15055 | biostudies-arrayexpress
UnknownTranscriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.
We hypothesized that small molecule transcriptional perturbation could be harnessed to target a cellular dependency involving protein arginine methyltransferase 5 (PRMT5) in the context of methylthioadenosine phosphorylase (MTAP) deletion, seen frequently in malignant pleural mesothelioma (MPM). Her...
S-EPMC8016828 | biostudies-literature
TranscriptomicsRNA-SEQ of epithelioid mouse mesothelioma treated with or without CSF1R inhibitor
Mesothelioma arises in humans after prolonged chronic inflammation driven by the presence of inhaled asbestos fibres in the chest cavity. We have generated a genetically engineered mouse model of mesothelioma that combines CRE-mediated deletion of 3 disease-relevant tumour suppressor genes, namely ...
ORGANISM(S): Mus musculus 
2023-06-03 | E-MTAB-12998 | biostudies-arrayexpress
MetabolomicsGNPS - Absent expansion of Axin2 hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in regeneration
Background & Aims: Mouse models of lineage tracing have helped to describe the important subpopulations of hepatocytes responsible for liver regeneration. However, conflicting results have been obtained from different models. Here we aimed to reconcile these conflicting reports by repeating a key li...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-18 | MSV000091082 | GNPS
UnknownThe tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group.
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potenti...
S-EPMC8636568 | biostudies-literature
UnknownPitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.
Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been...
S-EPMC7217863 | biostudies-literature
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