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TranscriptomicsTranscription profiling of Drosophila Roo lines grown on lead containing food to investigate lead toxicity
75 Diosophilia Roo lines, recominant inbred lines, were raised to adulthood either on conventional diet or diet supplemented with lead acetate. Whole flies were used for RNA extraction. RNA was run on Dros Genome 2 arrays. Each line also genotyped for 88 markers; Control food consisted of standard c...
ORGANISM(S): Drosophila melanogaster 
2009-06-08 | E-GEOD-11695 | biostudies-arrayexpress
ProteomicsImpact of intermittent lead exposure on hominid brain evolution
Lead Exposure and Human Brain Evolution: A 2-Million-Year Perspective This study reveals that lead exposure was pervasive throughout human evolution, not just a modern phenomenon. Researchers analyzed 51 fossil teeth from multiple hominid species spanning 2+ million years across three continents, fi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD067623 | Pride
Lead exposure  hominid brain evolution  nova1–foxp2 axis 
TranscriptomicsEffects of Developmental Lead Exposure on the Hippocampal Transcriptome.
In this study we analyzed the effects of lead-exposure up hippocampal gene expression in males and females exposed to 0ppm, 250ppm and 750ppm lead during two different developmental periods, perinatal (in utero through to weaning at PND21) and postnatal (PND0-PND45). All tissue was taken at PND 55....
ORGANISM(S): Rattus norvegicus 
2012-05-30 | E-GEOD-38348 | biostudies-arrayexpress
TranscriptomicsGenetic Diversity Influences the Response of the Brain to Developmental Lead Exposure.
In this study we analyzed the effects of lead-exposure up hippocampal gene expression in males and females exposed to 0ppm, 250ppm and 750ppm lead during two different developmental periods, perinatal (in utero through to weaning at PND21) and postnatal (PND0-PND45), across three strains (Fischer, L...
ORGANISM(S): Rattus norvegicus 
2014-04-10 | E-GEOD-56666 | biostudies-arrayexpress
ProteomicsThiol metabolic heterogeneity in immune cells causes distinct molecular mechanisms of toxicity upon chronic lead exposure
Lead pollution is global, billions of people are chronically exposed to lead. Biological thiols are nature sequesters of lead. Human immune system is highly vulnerable to lead, unfortunately the underlying mechanism remains unknown. Using mass cytometry and mass spectrometry, we systematically ident...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-10-30 | PXD057344 |
TranscriptomicsInfluence of Water Chemistry on Toxicogenomics of Chronic Lead Toxicity to the Fathead Minnow (Pimephales promelas)
Despite major successes in reducing the risks of lead (Pb) exposure over the past few decades, two issues of considerable importance remain unresolved: (1) how differences in water chemistry influence acute and chronic Pb toxicity, and (2) the elucidation of specific toxic mechanisms and modes of a...
ORGANISM(S): Pimephales promelas 
2008-04-06 | E-GEOD-8404 | biostudies-arrayexpress
ProteomicsImpact of neonatal lead exposure on memory: A study highlighting the association between hippocampal synaptic proteome and cognitive decline in rats
Lead (Pb2+) is a heavy metal ubiquitously present in the environment, with unknown essential functions to sustain life. The detrimental effects of Pb2+ on health are known since ancient times, which is also well supported by scientific literature. Incidentally, Pb2+ toxicity is more severe in childr...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-10 | PXD034212 | Pride
Lead toxicity Proteomics Hippocampus Memory impairment 
TranscriptomicsLead Modulates trans- and cis-eQTLs in Drosophila melanogaster Heads
The goal was to study the effects of lead exposure on gene expression and identify the lead-responsive genes. After detecting 1,536 cis-eQTLs (FDR ≤ 10%) and 952 trans-eQTLs, we focused our analysis on Pb-sensitive “trans-eQTL hotspots”. 158 randomly selected Drosophila Synthetic Population Re...
ORGANISM(S): Drosophila melanogaster 
2016-06-10 | E-GEOD-83141 | biostudies-arrayexpress
UnknownRisk factors of renal dysfunction and their interaction in level-low lead exposure paint workers.
Not available
S-EPMC5910569 | biostudies-literature
TranscriptomicsTranscriptome changes for Hirschfeldia incana in response to lead exposure
Experiments were achieved on Hirschfeldia incana, a Brassicaceae collected from metalliferous mine spoils as a Pb accumulator plant. Transcriptional profiling of roots and shoots from plants treated with lead were compared to plants treated in similar conditions without lead. Four weeks old H. incan...
ORGANISM(S): Hirschfeldia incana 
2015-01-28 | E-GEOD-65332 | biostudies-arrayexpress
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