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ProteomicsVitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional WRN mutant protein
Werner syndrome (WS) is a premature aging disorder caused by mutations in a DNA helicase/exonuclease. Mice lacking the helicase domain of the Wrn protein orthologue exhibit transcriptomic and metabolic alterations, some of which are reversed by vitamin C. Recent studies on the liver of these animals...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-02 | PXD007758 | Pride
Mouse model Liver proteome Lc-msms shotgun Vitamin c Endoplasmic reticulum Werner syndrome Label free quantification 
UnknownDairy Intake Modifies the Level of the Bile Acid Precursor and Its Correlation with Serum Proteins Associated with Cholesterol Clearance in Subjects with Hyperinsulinemia.
Not available
S-EPMC10675775 | biostudies-literature
ProteomicsIntegrated liver and serum proteomics reveal sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model
Werner syndrome is a progeroid disorder caused by mutations in a protein (Wrn) containing both a DNA exonuclease and DNA helicase domain. In this study, we identified proteins that exhibit abundance differences in the serum and liver tissue of wild type and Wrn mutant mice at four and ten months of ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-04 | MSV000091632 | MassIVE
UnknownImpact of cardiac surgical timing on the neurodevelopmental outcomes of newborns with Complex congenital heart disease (CHD).
Not available
S-EPMC10077148 | biostudies-literature
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