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TranscriptomicsConserved non-coding sequence 2 (CNS2) of the Foxp3 genomic locus is essential for the function and stability of regulatory T cells during their activation
Regulatory T (Treg) cells play an indispensable role in immune homeostasis. The development and function of Tregs are dependent on transcriptional factor Foxp3, but how constant expression of Foxp3 is maintained in Tregs is not clear. Here we show that ablation of the conserved non-coding DNA seque...
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-57272 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 3T3-MEFs derived from wild-type and SMRT RID mutants
SMRT (silencing mediator of retinoid and thyroid hormone receptors) is recruited by numerous transcription factors to mediate lineage and signal dependent transcriptional repression. We generated a knock-in mutation in the receptor interaction domain (RID) of SMRT (SMRTmRID) that solely disrupts it...
ORGANISM(S): Mus musculus 
2009-01-18 | E-GEOD-13143 | biostudies-arrayexpress
UnknownMissing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.
Not available
S-EPMC6877588 | biostudies-literature
UnknownRadioembolisation with yttrium‒90 microspheres versus sorafenib for treatment of advanced hepatocellular carcinoma (SARAH): study protocol for a randomised controlled trial.
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S-EPMC4265525 | biostudies-literature
UnknownExome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis.
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S-EPMC3702264 | biostudies-literature
UnknownThe "All of Us" Research Program.
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S-EPMC8291101 | biostudies-literature
UnknownTGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome.
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S-EPMC4033668 | biostudies-literature
UnknownCommon and rare von Willebrand factor (VWF) coding variants, VWF levels, and factor VIII levels in African Americans: the NHLBI Exome Sequencing Project.
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S-EPMC3724194 | biostudies-literature
UnknownAnalysis of 6,515 exomes reveals the recent origin of most human protein-coding variants.
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S-EPMC3676746 | biostudies-literature
UnknownRare loss of function variants in candidate genes and risk of colorectal cancer.
Not available
S-EPMC6283057 | biostudies-literature
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