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TranscriptomicsAttenuation of miR-126 activity expands HSC in vivo without exhaustion
Life-long blood cell production is governed through the poorly understood integration of cell-intrinsic and -extrinsic control of hematopoietic stem cell (HSC) quiescence and activation. MicroRNAs (miRNAs) coordinately regulate multiple targets within signaling networks making them attractive candid...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-40458 | biostudies-arrayexpress
ProteomicsQuantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies
Large-scale single-cell analyses are of fundamental importance in order to capture biological heterogeneity within complex cell systems, but have largely been limited to RNA-based technologies. Here we present a comprehensive benchmarked experimental and computational workflow, which establishes glo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-21 | MSV000090570 | MassIVE
TranscriptomicsHuman hematopoietic stem cell expansion through modulation of lineage-associated gene expression programs
Hematopoietic stem cells (HSCs) must balance self-renewal and lineage differentiation to regenerate the hematopoietic system throughout life. HSCs exhibit lineage-associated gene expression that keeps them responsive to demands of mature blood production. However, it is not known whether this proces...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-45486 | biostudies-arrayexpress
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