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Interactions between biomolecules underlie all cellular processes, and ultimately control cell fate. Perturbation of native interactions through mutation, changes in expression levels, or external stimuli leads to altered cellular physiology and can result in either disease or therapeutic effects. M...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-19 | MSV000090929 | MassIVE
Extracellular vesicles (EVs) have emerged as promising delivery vehicles for RNA-based therapeutics because of their advantages over other mRNA delivery systems, including their excellent biosafety and biocompatibility, stability against degradation, and the ability to cross physiological barriers s...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-10 | PXD045239 | Pride
To explore the role of miR-22 in the heart, we generated miR-22 null and transgenic mice. Cardiac transgenic overexpression of miR-22 in vivo led to cardiac hypertrophy that evolved into progressive dilated cardiomyopathy (DCM) in unstressed hearts. We found that miR-22 directly regulates two transc...
ORGANISM(S): Mus musculus 
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