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TranscriptomicsHCT116 cells isogenic for p53 expression upon treatment with actinomycin D and nutlin-3
HCT116 wild type cells express p53. The isogenic HCT116 p53KO cells have the p53 gene knocked out. Cells were treated for 16 hours. Dosages for actinomycin D treatment was 1 nM, 10 nM, and 100 nM. Dosage for nutlin-3 was 4 uM. Keywords: dose response Measuring the gene expression profile of the is...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-12459 | biostudies-arrayexpress
ProteomicsThe AMBRA1 E3 ligase adaptor regulates Cyclin D protein stability
Here we describe AMBRA1 as the main regulator of Cyclin D protein degradation. We first identify AMBRA1 as the top candidate in a genome-wide CRISPR/Cas9 loss-of-function screen investigating the genetic basis of resistance to chemical CDK4/6 inhibition. AMBRA1 loss results in high protein levels of...
ORGANISM(S): Homo sapiens (Human) 
2021-07-24 | PXD021789 | Pride
Human Cancer Cyclin d Cell cycle 
UnknownQuantum game strategy solution for R&D cartel: Reorganizing government R&D investment strategy in Korea.
Not available
S-EPMC11620664 | biostudies-literature
TranscriptomicsmRNA-Seq of head tissue from Drosophila mojavensis
We sequenced mRNA from head tissue of females and male of Drosophila mojavensis to identify genes differentially expressed between the sexes and sex-specific alternative splicing events. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pa...
ORGANISM(S): Drosophila mojavensis 
2010-04-11 | E-GEOD-20882 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of the response to D-limonene in Saccharomyces cerevisiae
Metabolic engineering of Saccharomyces cerevisiae for efficient monoterpenes production was mostly restricted by the limited tolerance to these chemicals. Understanding of the molecular mechanisms underlying the tolerance of S. cerevisiae to monoterpenes was essential for the de novo biosynthesis th...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-23 | E-GEOD-34665 | biostudies-arrayexpress
ProteomicsGasdermin D-dependent secretome analysis from primary murine microglia
To identify NLRP3-gasdermin D-dependent secreted proteins, wild type or gasdermin D-deficient microglia were treated with NLRP3 agonist (LPS + ATP). Cell-free supernantants from microglia were then analyzed by mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2025-01-07 | PXD051438 | Pride
Mouse Microglia Secretome Lc-ms/ms 
TranscriptomicsTiling microarray analysis of gene expression profile of Escherichia coli galT mutant cells under D-galactose-stressed condition
To understand the altered gene expression by D-galactose in galT cells, the cells were grown in the presence and absence of D-galactose and tiling array analysis was performed for transcriptome profiling. A galT defect causes the disease Galactosemia in human. This work helps us to study the human m...
ORGANISM(S): Escherichia coli 
2013-12-17 | E-GEOD-42821 | biostudies-arrayexpress
ProteomicsDaphnia pulex_Lysine acetylation
Daphnia (Daphnia pulex) is a small planktonic crustacean and a key constituent of aquatic ecosystems. It is commonly used as a model organism for studying environmental toxic challenges. In the past decade, a Daphnia genomic information and proteomic dataset has been developed. This dataset has expa...
ORGANISM(S): Daphnia pulex (Water flea) 
2016-01-05 | PXD002441 | Pride
D. pulex  lysine acetylation  post-translational modification  proteomics 
TranscriptomicsExpression data from C2C12 mouse myoblast with treatment actinomycin D
Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay also play a major role in achieving rapid and massive changes in mRNA abundance. Moreover, just as transcription fact...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-21233 | biostudies-arrayexpress
UnknownAssociation of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein.
Not available
S-EPMC4966337 | biostudies-literature
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