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ProteomicsQuantitative proteomics of the lung in a Thbs1 cell specific knockout model after pseudomonal injury in mice
An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes (Mgks) and platelets play important roles in hemostasis, their impact on the matrix in lung injury is not fully understood. We utilized quantitative proteomics to...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-20 | PXD071231 | Pride
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
GenomicsContext Dependency of Set1/COMPASS Mediated H3 Lysine 4 Trimethylation
The stimulation of trimethylation of histone H3 lysine 4 (H3K4) by H2B monoubiquitination (H2Bub) has been widely studied with multiple mechanisms proposed for this form of histone crosstalk. Cps35/Swd2 within COMPASS is considered to bridge these processes. However, a truncated form of Set1 (762-Se...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-09 | E-GEOD-53241 | biostudies-arrayexpress
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
Unknown<i>SOS2</i> and <i>ACP1</i> Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.
Not available
S-EPMC5328154 | biostudies-literature
UnknownRare and low-frequency coding variants alter human adult height.
Not available
S-EPMC5302847 | biostudies-literature
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