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Zika virus (ZIKV), an arbovirus of global concern, remodels intracellular membranes to form replication sites. We performed comprehensive lipidomics to create a lipid network map during ZIKV infection. We found that ZIKV significantly alters host lipid composition, with the most striking changes see...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-15 | MSV000085584 | GNPS
Lipidomic analysis of Huh7 cells infected with Zika FSS13025 at an MOI of ~10. Samples collected at 24 and 48 hrs post infection.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-29 | MSV000083079 | GNPS
Lipidomic analysis of Huh7 cells infected with Zika FSS13025 at an MOI of ~10. Samples collected at 24 and 48 hrs post infection.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-29 | MSV000083079 | MassIVE
This research identifies a novel protein required for paramutation at the maize purple plant1 locus. This 'required to maintain repression2' (RMR2) protein represents the founding member of a plant-specific clade of hypothetical proteins. We show that RMR2 is required for transcriptional repression ...
ORGANISM(S): Zea mays 

The genetic makeup of an individual strongly influences the risk of developing systemic lupus erythematosus (SLE). The identification of genes that predispose an individual to SLE will lead to earlier and better diagnosis, better treatments, and possibly prevention.

To this end, t...

"Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (lambda(S) = approximately 30). We performed a genome-wide association scan using 317,501 SNPs in 720 women of European ancestry with SLE and in 2,337 controls,...

The Genetics of Type 2 Diabetes Consortium (GoT2D) is a collaboration between the University of Michigan, the Broad Institute and the Wellcome Trust Centre for Human Genetics. The overall aim is to extend upon recent efforts, such as genome-wide association studies (GWAS) and large scale meta-analys...
The GoT2D study includes ~2800 samples, half T2D cases and half T2D controls, of Northern European ancestry sequenced over 3 three technologies: deep whole exome sequencing, low-pass (4x) whole genome sequencing, and OMNI 2.5M genotyping. Samples were ascertained to be phenotypically "extreme" (e.g....
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