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TranscriptomicsThe effect of IAN on P. aeruginosa virulence
Intercellular signal indole and its derivative hydroxyindoles inhibit Escherichia coli biofilm and diminish Pseudomonas aeruginosa virulence. However, indole and bacterial indole derivatives were unstable in microbial community due to the widespread of diverse oxygenases that could quickly degrade ...
ORGANISM(S): Pseudomonas aeruginosa 
2011-02-20 | E-GEOD-21508 | biostudies-arrayexpress
TranscriptomicsIdentification of Biofilm Inhibitors from Streptomyces Strains for Reducing Pseudomonas aeruginosa Biofilm Formation
Biofilms are ubiquitous in natural, medical, and engineering environments. While most antibiotics that primarily aim to inhibit cell growth may result in bacterial drug resistance, biofilm inhibitors do not affect cell growth and there is less chance of developing resistance. This work sought to id...
ORGANISM(S): Pseudomonas aeruginosa 
2013-03-21 | E-GEOD-28194 | biostudies-arrayexpress
TranscriptomicsThe Apple Flavonoid Phloretin Inhibits Escherichia coli O157:H7 Biofilm Formation and Ameliorates Colon Inflammation in Rat
Pathogenic biofilms have been associated with persistent infections due to high resistance to antimicrobial agents while commensal biofilms often fortify host immune system. Hence, controlling biofilm formation of both pathogenic bacteria and commensal bacteria is important in bacteria-related dise...
ORGANISM(S): Escherichia coli 
2011-11-22 | E-GEOD-28144 | biostudies-arrayexpress
UnknownTumor immune-gene expression profiles and peripheral immune phenotypes associated with clinical outcomes of locally advanced pancreatic cancer following FOLFIRINOX.

Background

A comprehensive analysis of peripheral immune cell phenotypes and tumor immune-gene expression profiles in locally advanced pancreatic cancer patients treated with neoadjuvant chemotherapy in a phase II clinical trial was carried out.

Methods

Patients were treated with neoa...
S-EPMC9271485 | biostudies-literature
UnknownNeoadjuvant modified FOLFIRINOX followed by postoperative gemcitabine in borderline resectable pancreatic adenocarcinoma: a Phase 2 study for clinical and biomarker analysis.

Background

Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery.

Methods

This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 c...
S-EPMC7403346 | biostudies-literature
UnknownLaparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: 5-Year Outcomes of the KLASS-02 Randomized Clinical Trial.

Importance

The long-term safety of laparoscopic distal gastrectomy for locally advanced gastric cancer (AGC) remains uncertain given the lack of 5-year follow-up results.

Objective

To compare the 5-year follow-up results in patients with clinically AGC enrolled in the Korean Laparoend...
S-EPMC9301593 | biostudies-literature
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