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ProteomicsTreatment with sodium butyrate has therapeutic benefits for Machado-Joseph disease through the induction of autophagy
Machado-Joseph disease (MJD) is a fatal neurodegenerative disease caused by expansion of the trinucleotide repeat region within the ATXN3/MJD gene. Mutation of ATXN3 causes formation of neurotoxic ataxin-3 protein aggregates, neurodegeneration and motor deficits. Here we investigated the therapeutic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-24 | PXD024626 | Pride
Autophagy Trinucleotide repeat disease Label-free proteomics Spinocerebellar ataxia 3 Flow cytometry Sodium butyrate Microbiota Machado-joseph disease Polyq Neurodegeneration Zebrafish 
MetabolomicsAn Integrated Biochemical, Proteomics, and Metabolomics Approach for Supporting Medicinal Value of Panax ginseng Fruits (GC-MS assay)
Panax ginseng roots are well known for their medicinal properties and have been used in Korean and Chinese traditional medicines for 1000s of years. However, the medicinal value of P. ginseng fruits remain poorly characterized. Using gas chromatography-time of flight mass spectrometry (GC-TOF MS), 6...
2016-11-18 | MTBLS350 | MetaboLights
UnknownGlobal Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.
Not available
S-EPMC8493485 | biostudies-literature
MetabolomicsIdentification of Metabolites and Transcripts Involved in Salt Stress and Recovery in Peanut
Peanut (Arachis hypogaea L.) is considered as a moderately salt-sensitive species and thus soil salinity can be a limiting factor for peanut cultivation. To gain insights into peanut plant physiology in response to salt stress and alleviation, we comprehensively characterized leaf relative electroly...
2019-03-19 | MTBLS583 | MetaboLights
UnknownBiomarker Panel for Chronic Graft-Versus-Host Disease.
Not available
S-EPMC5012688 | biostudies-literature
UnknownAllele-specific silencing of dominant disease genes.
Not available
S-EPMC165852 | biostudies-literature
UnknownGenetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.
Not available
S-EPMC5477828 | biostudies-literature
UnknownCetuximab Plus Chemoradiotherapy for HIV-Associated Anal Carcinoma: A Phase II AIDS Malignancy Consortium Trial.
Not available
S-EPMC5455422 | biostudies-literature
UnknownNovel role of prostate cancer risk variant rs7247241 on PPP1R14A isoform transition through allelic TF binding and CpG methylation.
Not available
S-EPMC9122641 | biostudies-literature
MetabolomicsMetabolic analysis of the response of Pseudomonas putida DOT-T1E strains to toluene using Fourier transform infrared spectroscopy and gas chromatography mass spectrometry
To elucidate any observable metabolic alterations during interactions of several strains of Pseudomonas putida (DOT-T1E, and its mutants DOT-T1E-PS28 and DOT-T1E-18) with the aromatic hydrocarbon toluene, metabolomic approaches were employed. Initially, Fourier-transform infrared (FT-IR) spectroscop...
2016-08-23 | MTBLS319 | MetaboLights
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