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TranscriptomicsOver-expression of YAP1 in NCI-H716 colorectal cancer cells
YAP1 plays importance roles in development of colorectal cancer as evidenced by their overexpression in colorectal cancer and their expression promoted cell proliferation and survival of colorectal cancer cells. In order to understand potential roles of YAP1 in colorectal cancer, we over-expressed c...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-50490 | biostudies-arrayexpress
TranscriptomicsGene expression profile of TARDBP in hepatocellular carcinoma cell line (SK-Hep1)
TARDBP is TARDBP (TDP-43) is a DNA/RNA binding protein and was mutated in human amyotrophic lateral sclerosis (ALS). However, its function in human cancer has not been fully identified, yet.Thus, We carried out microarray to investigate the down-stream target genes of TARDBP after silencing TARDBP i...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-37640 | biostudies-arrayexpress
TranscriptomicsGene expression profile of FOXM1 with Doxorubicin in MDA-MB-231 breast cancer cells
Transcription factors (TFs) play a crucial role in diverse cellular physiology by controlling down-stream target genes. It has been well recognized that TFs are attractive target for treating human cancer since transcriptional activity or gene expression level of TFs can be directly modulated. To ex...
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-25741 | biostudies-arrayexpress
TranscriptomicsRobust prognostic biomarkers for EAC identified by systems-level characterization of tumor transcriptome
Despite continual efforts to rationalize a prognostic stratification of patients with esophageal adenocarcinoma (EAC) before treatment, current staging system only shows limited success owing to the lack of molecular and genetic markers that reflect prognostic features of the tumor. To develop molec...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-13898 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression patterns signifying loss of the mouse tumor supressor Gprc5a in lung epithelial cells
Increasing the understanding of the impact of changes in oncogenes and tumor suppressor genes is essential for improving the management of lung cancer. Recently, we identified a new mouse lung-specific tumor suppressor - the G-protein coupled receptor 5A (Gprc5a). We sought to understand the molecul...
ORGANISM(S): Mus musculus 
2010-04-13 | E-GEOD-21309 | biostudies-arrayexpress
TranscriptomicsGene expression signature-based novel prognostic risk score in gastric cancer
Despite continual efforts to establish pre-operative prognostic model of gastric cancer by using clinical and pathological parameters, a staging system that reliably separates patients with early and advanced gastric cancer into homogeneous groups with respect to prognosis does not exist. With use o...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-13861 | biostudies-arrayexpress
TranscriptomicsUnexpected roles of ATP11B in platinum resistance
Platinum compounds display clinical activity against a wide variety of solid tumors. However, resistance to these agents is a major limitation in cancer therapy. Reduced platinum uptake and increased platinum export are examples of resistance mechanisms that limit the extent of DNA damage. Here, we ...
ORGANISM(S): Homo sapiens 
2013-01-23 | E-GEOD-43694 | biostudies-arrayexpress
TranscriptomicsHuman Hepatocellular Carcinoma study
Global gene expression patterns of 91 human hepatocellular carcinomas (HCC) were analyzed to define the molecular characteristics of the tumors and to test the prognostic value of the expression profiles. Total RNAs were isolated from frozen liver tissue using CsCl density gradient centrifugation me...
ORGANISM(S): Homo sapiens 
2004-10-28 | E-GEOD-1898 | biostudies-arrayexpress
TranscriptomicsMouse Hepatocellular Carcinoma Study
Genetically modified mice have been extensively used for analyzing the molecular events that occur during the tumor development. However, in many cases, if not all, it is uncertain to what extent the mouse models reproduce features observed in the corresponding human conditions. This is due largely ...
ORGANISM(S): Mus musculus 
2004-10-28 | E-GEOD-1897 | biostudies-arrayexpress
Genomicsena-DATASET-KAIST-03-05-2017-03:08:17:539-449 - samples
This dataset includes the high-throughput sequencing data from a study entitled "Clonal History and Genetic Predictors of Transformation into Small Cell Carcinomas from Lung Adenocarcinomas". Whole-genome sequencing libraries were generated by PCR-free methods, and sequencing run was made in HiSeq X...
EGAD00001003315 | EGA
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