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TranscriptomicsOver-expression of YAP1 in NCI-H716 colorectal cancer cells
YAP1 plays importance roles in development of colorectal cancer as evidenced by their overexpression in colorectal cancer and their expression promoted cell proliferation and survival of colorectal cancer cells. In order to understand potential roles of YAP1 in colorectal cancer, we over-expressed c...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-50490 | biostudies-arrayexpress
TranscriptomicsEpigenetic silencing of noncoding RNA nc886 provokes oncogenes during esophageal tumorigenesis
nc886 is a 101 nucleotides long non-coding RNA that is also known as a precursor microRNA or a vault RNA. nc886 has been suggested to be a tumor suppressor, mainly inferred by its expression pattern as well as its genomic location at human chromosome 5q31, a locus for a tumor suppressor gene(s). Pre...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-51732 | biostudies-arrayexpress
TranscriptomicsThe orphan nuclear receptor NR4A1 (Nur77, TR3) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells
NR4A1 (Nur77, TR3) is an orphan nuclear receptor that is overexpressed in pancreatic cancer cells and tumors and exhibits pro-oncogenic activity. Knockdown of NR4A1 by RNA interference (siNR4A1) in Panc1 cells and analysis of the proteome resulted in induction of several markers of endoplasmic retic...
ORGANISM(S): Homo sapiens 
2014-04-30 | E-GEOD-46994 | biostudies-arrayexpress
TranscriptomicsGene expression analyses of GSC11 cell in stem cell culture conditions or in differentiation conditions for 1, 3, or 7 days
Although fetal bovine serum (FBS) induces the differentiation of cancer stem cells, the underlying mechanism by which this is accomplished has not been clarified. Whether reactive oxygen species affect the differentiation of cancer stem cells in solid tumors as they do in normal stem cells is not kn...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-28220 | biostudies-arrayexpress
TranscriptomicsPeriostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor invasive signature in esophageal cancer
Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. We report that periostin, a highly expressed cell a...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-21293 | biostudies-arrayexpress
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