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UnknownPhase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma.
Not available
S-EPMC4588714 | biostudies-literature
UnknownCharacteristics of Germline and Somatic Mutations of DNA Repair Genes in Korean Men with Prostate Cancer.
Not available
S-EPMC12798357 | biostudies-literature
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells
This SuperSeries is composed of the following subset Series: GSE35265: Analysis of global gene expression profiles of hPAF1 deficiency on unstimulated A549 cells GSE35266: Analysis of global gene expression profiles of hPAF1 deficient A549 cells during infection with H1N1 influenza A virus or vesicu...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35268 | biostudies-arrayexpress
GenomicsSynthetic antagonist of a histone reader reveals and targets genes essential for inflammation
Post-translational modifications of histones determines cell lineage- or signal-specific gene expression. Depending on the type and combination of modifications, histones bind to functionally distinct effector proteins ('readers') that control gene activation or silencing. The current pharmacologic...
ORGANISM(S): Mus musculus 
2010-11-10 | E-GEOD-21910 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficiency on unstimulated A549 cells
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35265 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells during infection with H1N1 influenza A virus or vesicular stomatitis virus (VSV)
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35266 | biostudies-arrayexpress
TranscriptomicsAnalysis of global gene expression profiles of hPAF1 deficient A549 cells during stimulation with PR8/∆NS1 influenza virus, IFNβ1 or Poly(I:C)
Viral infection is commonly associated with virus-driven hijacking of host proteins. We describe a novel mechanism by which influenza virus impacts host cells through the interaction of influenza NS1 protein with the infected cell epigenome. We show that the NS1 protein of influenza A H3N2 targets t...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35267 | biostudies-arrayexpress
ProteomicsProteogenomic analysis of chemo-refractory high grade serous ovarian cancer
To improve our understanding of the molecular basis of chemo-refractory high grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two independent validation cohorts (spanning four academic centers...
ORGANISM(S): Homo Sapiens 
PXD040742 | panorama
UnknownGenome-wide association study of endometrial cancer in E2C2.
Not available
S-EPMC3898362 | biostudies-literature
UnknownGWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.
Not available
S-EPMC5868213 | biostudies-literature
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