Lee W L WL - OmicsDI

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Unknown (237)
Genomics (21)
Transcriptomics (14)
Proteomics (5)
Metabolomics (2)

Organisms

Homo sapiens (32)
Mus musculus (5)
Gallus gallus (1)
Rattus norvegicus (1)
cellular organisms (1)

Repository

EGA (21)
biostudies-arrayexpress (14)
jPOST (3)
MetaboLights (2)
pride (2)

Tissue

Cardiac muscle cell (1)
Cell culture (1)
Heart (1)
Lung (1)

Technology Type

Illumina 15K (8)
Mass spectrometry (2)
Mass Spectrometry (2)
Affymetrix 6.0 (1)
Illumina 1.2M, Affymetrix 6.0 (1)
Data-dependent acquisition (1)
Shotgun proteomics (1)

Instrument Platform

Liquid Chromatography MS - negative - reverse phase (2)
Liquid Chromatography MS - positive - reverse phase (2)

Publication Date

2013 (4)
2021 (4)
2015 (3)
2014 (2)
2011 (2)
2009 (2)
2007 (1)
2023 (1)
2022 (1)
2024 (1)

CHEBI ID

CHEBI:10049 (1)
CHEBI:10093 (1)
CHEBI:101085 (1)
CHEBI:109895 (1)
CHEBI:1109 (1)
CHEBI:12387 (1)
CHEBI:124991 (1)
CHEBI:125535 (1)
CHEBI:131887 (1)
CHEBI:131924 (1)
CHEBI:132448 (1)
CHEBI:132883 (1)
CHEBI:133026 (1)
CHEBI:133094 (1)
CHEBI:133657 (1)
CHEBI:133662 (1)
CHEBI:133756 (1)
CHEBI:133758 (1)
CHEBI:134092 (1)
CHEBI:134281 (1)
CHEBI:134418 (1)
CHEBI:134442 (1)
CHEBI:134454 (1)
CHEBI:134548 (1)
CHEBI:134583 (1)
CHEBI:135654 (1)
CHEBI:135736 (1)
CHEBI:135876 (1)
CHEBI:135893 (1)
CHEBI:135954 (1)

Metabolite Name

(1'S,2R,2'R,10'S,11'S,15'S)-17'-hydroxy-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane]-6',8'-diene-5,5'-dione (1)
(1-{1-[(4-hydroxy-3-methoxyphenyl)methyl]-7,8-dimethoxy-2,2-dimethyl-1,2,3,4-tetrahydro-2λ⁵-isoquinolin-2-yl}ethylidene)-λ⁴-oxidanyliumyl (1)
(10,14a-dihydroxy-2,2,4a,6a,6b,9,9,12a-octamethyl-docosahydropicen-13-yl)oxidanesulfonic acid (1)
(10S,14S)-10,14,20-trimethyl-16-methylidene-22-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁵,²³.0¹⁷,²²]tetracosan-5-ylium-7-olate (1)
(12aR)-4-(dimethylamino)-4a,5,10,12a-tetrahydroxy-6-methylidene-1,2,3,4,4a,5,5a,6,11,11a,12,12a-dodecahydrotetracene-1,3,11,12-tetrone (1)
(12aR)-7-chloro-4-(dimethylamino)-4,6,10,12a-tetrahydroxy-1,2,3,4,4a,5,5a,6,11,11a,12,12a-dodecahydrotetracene-1,3,11,12-tetrone (1)
(12aS)-4,7-bis(dimethylamino)-10,12,12a-trihydroxy-1,3,11-trioxo-9-(2-oxoacetamido)-1,2,3,4,4a,5,5a,6,11,11a,12,12a-dodecahydrotetracene-2-carboximidic acid (1)
(12aS)-9-{[2-(tert-butylamino)-1-hydroxyethylidene]amino}-4,7-bis(dimethylamino)-5,10,12,12a-tetrahydroxy-1,3,11-trioxo-1,2,3,4,4a,5,5a,6,11,12a-decahydrotetracene-2-carboximidic acid (1)
(13-{[5-(acetyloxy)-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1,6,6,11,15-pentamethyl-14-(6-methylhept-5-en-2-yl)-5-[(3,4,5-trihydroxyoxan-2-yl)oxy]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-9-yl)oxidanesulfonic acid (1)
(13R)-5-(3,4-dihydroxyphenyl)-6,9,17,19,21-pentahydroxy-13-(4-hydroxyphenyl)-4,12,14-trioxapentacyclo[11.7.1.0²,¹¹.0³,⁸.0¹⁵,²⁰]henicosa-2(11),3(8),5,9,15,17,19-heptaen-7-one (1)
(15Z)-Octadec-15-en-9,11,13-triynoic acid (1)
(1R)-1,4-bis({[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy})-3-hydroxy-5-(sulfooxy)cyclohexane-1-carboxylic acid (1)
(1R,16Z,24E,26E,28Z)-1,18,26,27-tetrahydroxy-19,30-dimethoxy-12-[1-(3-methoxy-4-oxocyclohexyl)propan-2-yl]-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0⁴,⁹]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone (1)
(1R,16Z,24E,26E,28Z)-1,18-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)propan-2-yl]-19,30-dimethoxy-15,17,21,23,29-pentamethyl-35-methylidene-11,36-dioxa-4-azatricyclo[30.3.1.0⁴,⁹]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone (1)
(1R,2R,3R,11S,12S,14R,26R)-5,6',7',12-tetrahydroxy-6-methoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4(9),5,7,15(23),16(20),21-hexaen-22-yl acetate (1)
(1R,2S,3R,4R,5S,6R,7S)-1,3,4,5,7,8,9,10,10-Nonachlorotricyclo[5.2.1.0²,⁶]dec-8-ene (1)
(1R,6S,12R,15S)-5,5-Dimethyl-11,13-dioxatetracyclo[7.5.1.0¹,⁶.0¹²,¹⁵]pentadec-8-ene (1)
(1R,9S,18Z,24R)-12-[1-(4-chloro-3-hydroxycyclohexyl)prop-1-en-2-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0⁴,⁹]octacos-18-ene-2,3,10,16-tetrone (1)
(1R,9S,18Z,24R)-12-[1-(4-chloro-3-methoxycyclohexyl)prop-1-en-2-yl]-17-ethyl-1,14-dihydroxy-13-(hydroxymethyl)-23,25-dimethoxy-19,21,27-trimethyl-11,28-dioxa-4-azatricyclo[22.3.1.0⁴,⁹]octacos-18-ene-2,3,10,16-tetrone (1)
(1S)-1,3,4-trihydroxy-5-(sulfooxy)cyclohexane-1-carboxylic acid (1)
(1S,16Z,24E,26E,28Z)-1,18-dihydroxy-12-{1-[4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-15-(hydroxymethyl)-19,30-dimethoxy-17,21,23,29,35-pentamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0⁴,⁹]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone (1)
(1S,16Z,24E,26E,28Z)-1,18-dihydroxy-12-{1-[4-(2-hydroxyethoxy)-5-methoxy-2-oxocyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0⁴,⁹]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone (1)
(1S,2R,10S,11S,14R,15R)-2,15-Dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-ene (1)
(1S,2S,10S,11S,15R)-14-(5,6-dimethylheptan-2-yl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-5,17-diol (1)
(1S,2S,5R,7R,10S,11S,14R,15S,17S)-14-[(1R)-1,2-Dihydroxyethyl]-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-5,14,17-triol (1)
(1S,2S,5S,10R,11S,14R,15R)-14-[(2R,5R)-5-Ethyl-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-ol (1)
(1S,2S,7S,10R,15R)-2,15-dimethyl-14-(1,4,6-trihydroxy-6-methylheptan-2-yl)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-5,9,16-triol (1)
(1S,5R,13R,17S)-15-[(1S,3S,5R,13R)-10,14-Dimethoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,14,16-pentaen-3-yl]-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraen-14-one (1)
(2-Aminoethoxy)[(2R)-2-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]-3-[(6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraenoyloxy]propoxy]phosphinic acid (1)
(2-Aminoethoxy)[(2R)-2-[(5Z,8Z,11Z)-icosa-5,8,11-trienoyloxy]-3-[(9Z)-octadeca-1,9-dien-1-yloxy]propoxy]phosphinic acid (1)

Study type

RNA-seq of coding RNA (7)
Transcription profiling by array (4)
ChIP-chip by tiling array (2)
Transcription profiling by MPSS (1)

Release Date

2022 (23)
2021 (23)
2015 (20)
2020 (20)
2024 (17)
2014 (16)
2011 (16)
2013 (14)
2025 (14)
2016 (14)
2009 (11)
2023 (11)
2018 (9)
2019 (7)
2012 (7)
2008 (7)
2017 (6)
2010 (6)
2007 (5)
2026 (5)

Lab affiliation

Department of Biochemistry and Pharmacology, The Bio21 Molecular Science & Biotechnology Institute, University of Melbourne, Melbourne, Australia (1)
Genome Insistute of Singapore (GIS) (1)

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Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia.

Not available

S-EPMC7408981 | biostudies-literature

Enhancer Transcripts Mark Active Estrogen Receptor Binding Sites

In this study, we used Global Run-On sequencing (GRO-seq), a method that assays the genome-wide location and orientation of all active RNA polymerases. We generated a global profile of active transcription at ERM-NM-1 binding sites in MCF-7 human breast cancer cells in response to short time course ...

ORGANISM(S): Homo sapiens

2013-05-08 | E-GEOD-43835 | biostudies-arrayexpress

Metabolomic fingerprinting of bull spermatozoa for identification of fertility signature metabolites

The objective of the study was to identify the fertility-associated metabolites in bovine spermatozoa using liquid chromatography-mass spectrometry (LC-MS). Six Holstein Friesian crossbred bulls (three high-fertile and three low-fertile bulls) were the experimental animals. Sperm proteins were isola...

2021-12-07 | MTBLS1071 | MetaboLights

Enhancer Transcripts Mark Active Estrogen Receptor Binding Sites using GRO-seq

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

2013-01-28 | E-GEOD-43836 | biostudies-arrayexpress

Signaling Pathways Deferentially Affect RNA Polymerase II Initiation, Pausing, and Elongation in Human Cells: TNF-alpha dependent signaling in AC16 cells

We used Global Run-on and Sequencing (GRO-seq) to measure the rate of transcription elongation by RNA polymerase II (Pol II) following gene activation. We observed that Pol II elongation rates can vary as much as 4-fold at different genomic loci and in response to two distinct cellular signaling pa...

ORGANISM(S): Homo sapiens

2013-04-10 | E-GEOD-41323 | biostudies-arrayexpress

MicroRNA mediation of endothelial inflammatory response to smooth muscle cells and its inhibition by atheroprotective shear stress.

Not available

S-EPMC4380766 | biostudies-literature

Signaling Pathways Deferentially Affect RNA Polymerase II Initiation, Pausing, and Elongation in Human Cells: Estrogen dependent signaling in MCF-7 cells

ORGANISM(S): Homo sapiens

2013-04-10 | E-GEOD-41324 | biostudies-arrayexpress

RNA-seq profiling of microdissected rat renal tubule segments

We sequenced mRNAs from glomeruli and 14 different rat renal tubule segments collected by hand microdissection. Collagenase-digested rat renal tubule segments were collected by hand microdissection. Poly(A)-mRNAs were captured from cell lysate and sequenced using paired-end protocol.

ORGANISM(S): Rattus norvegicus

2015-03-31 | E-GEOD-56743 | biostudies-arrayexpress

Global Analysis of the Immediate Transcriptional Effects of Estrogen Signaling Reveals a Rapid, Extensive, and Transient Response

We report the immediate effects of estrogen signaling on the transcriptome of breast cancer cells using Global Run-On and sequencing (GRO-seq). We found that estrogen signaling directly regulates a strikingly large fraction of the transcriptome in a rapid, robust, and unexpectedly transient manner. ...

ORGANISM(S): Homo sapiens

2011-05-05 | E-GEOD-27463 | biostudies-arrayexpress

Identification and functional characterization of long noncoding RNAs in breast cancer

In this study, we have integrated RNA-seq data from subcellular fractionated RNA (i.e., cytoplasm, nucleoplasm, and chromatin-associated) with GRO-seq data using a novel bioinformatics pipeline. This has yielded a comprehensive catalog of polyadenylated lncRNAs in MCF-7 cells, about half of which ha...

ORGANISM(S): Homo sapiens

2015-07-30 | E-GEOD-63189 | biostudies-arrayexpress

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