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GenomicsMistranslation accelerates the adaptation of Candida albicans to Fluconazole
The leucine CUG codon was reassigned to serine in the fungal pathogen Candida albicans. To clarify the biological role of this tuneable codon ambiguity on drug resistance, we evolved C. albicans strains that were engineered to mistranslate the CUG codon at constitutively elevated levels, in the pres...
ORGANISM(S): Candida albicans 
2016-10-27 | E-SYBR-13 | biostudies-arrayexpress
TranscriptomicsGenomics of the individual heat shock response
The transcriptional response to heat shock is essential for cells to function effectively under stress. This is a highly heritable trait but the nature and extent of inter-individual variation in heat shock response are not well established. This dataset consists of the global transcription profiles...
ORGANISM(S): Homo sapiens 
2016-08-26 | E-MTAB-4953 | biostudies-arrayexpress
TranscriptomicsContext-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele
IL-7 is a key factor in T-cell immunity and IL7R polymorphisms are implicated in susceptibility to autoimmune conditions. IL7R mRNA is induced in stimulated monocytes in a genetically determined manner. The aim this experiment was i) to characterise changes in gene expression with LPS, and ii) post-...
ORGANISM(S): Homo sapiens 
2019-08-17 | E-MTAB-8225 | biostudies-arrayexpress
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