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TranscriptomicsMuscle Hypertrophy Induced by Myostatin Inhibition Accelerates Degeneration in Dysferlinopathy
Because myostatin normally limits skeletal muscle growth, there is an extensive effort to develop myostatin inhibitors for clinical use. One potential concern is that in patients with muscle degenerative diseases, inducing hypertrophy may increase stress on dystrophic fibers. Here, we show that bl...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-62945 | biostudies-arrayexpress
MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
TranscriptomicsExposure of radiation on mouse lung
This study was designed to identify molecular changes induced by radiation in mouse lung. Mouse left lung was irradiated with a single dose of radiation. Total RNA from the irradiated lung tissue was subject to single channnel microarray.
ORGANISM(S): Mus musculus 
2014-08-21 | E-GEOD-60541 | biostudies-arrayexpress
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