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TranscriptomicsExpression data from mouse primary brown preadipocytes
Brown adipocytes are specialized for heat generation and energy expenditure as a defense against cold and obesity. Recent studies demonstrate that brown adipocytes arise in vivo from a Myf5-positive, myoblastic progenitor by the action of PRDM16. Here, we identified a brown fat-enriched miRNA cluste...
ORGANISM(S): Mus musculus 
2011-05-02 | E-GEOD-27614 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of female identical twins
Genome wide DNA methylation profiling of blood samples from eight female identical twins of Han Chinese for forensic age prediction, age 21 to 32. The Illumina Infinium HumanMethylation450 BeadChip was used to obtain DNA methylation profiles across approximately 485,000 CpGs at a single-nucleotide r...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-65638 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNA as regulatory switch of protein turnover
Long intervening noncoding RNAs (lincRNAs) are prevalent genes with poorly understood functions. Here we discover a pathway of lincRNA-regulated proteolysis. The enhancer-like lincRNA HOTTIP extends the half-life of its binding protein WDR5, a subunit of the MLL H3K4 methylase complex, resulting in ...
ORGANISM(S): Mus musculus 
2013-02-18 | E-GEOD-36513 | biostudies-arrayexpress
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