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ProteomicsDiscovery of a monoacylglycerol lipase inhibitor that harnesses the therapeutic potential of endocannabinoid signaling without CNS-mediated adverse side effects or physical dependence.
Chemical proteomics of LEI-515 in mouse lung, liver and brain tissue to assess the selectivity of the inhibitor.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD042220 | Pride
Brain Lung Liver Mouse Chemical proteomics 
UnknownComparative transcriptomic analysis of the flower induction and development of the Lei bamboo (Phyllostachys violascens).
Not available
S-EPMC6929269 | biostudies-literature
MetabolomicsMulti-omics analysis reveals immune-metabolic dysregulation in DNASE1L3-deficient mouse liver

This study investigates the role of DNASE1L3 deficiency in hepatic immune and metabolic regulation. Using transcriptomics, proteomics, and metabolomics, we characterize changes in Kupffer cell polarization, ER stress, iron metabolism, and ferroptosis in DNASE1L3 knockout mice.'

2025-10-25 | MTBLS13057 | MetaboLights
UnknownA New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis.
Not available
S-EPMC8624330 | biostudies-literature
GenomicsThe RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner
Chromatin insulators are DNA-protein complexes situated throughout the genome that contribute to higher order organization and demarcation into distinct transcriptional domains. Mounting evidence in different species implicates RNA and RNA-binding proteins as regulators of chromatin insulator activ...
ORGANISM(S): Drosophila melanogaster 
2014-04-18 | E-GEOD-51462 | biostudies-arrayexpress
UnknownOrganic Acid-Induced Structural Modifications Improve Melt-Stretch Properties and Mouthfeel of Plant-Based Cheese Alternatives.
Not available
S-EPMC12607658 | biostudies-literature
GenomicsTissue-specific regulation of chromatin insulator function
Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein, Shep...
ORGANISM(S): Drosophila melanogaster 
2012-11-30 | E-GEOD-40797 | biostudies-arrayexpress
ModelsLei2001_Yeast_Aerobic_Metabolism
This the model from the article: A biochemically structured model for Saccharomyces cerevisiae. Lei F, Rotbøll M, Jørgensen SB. J Biotechnol. 2001 Jul 12;88(3):205-21. PMID: 11434967 ,DOI: 10.1016/S0168-1656(01)00269-3 ...
2024-09-02 | BIOMD0000000245 | BioModels
TranscriptomicsGenome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila
Chromatin insulators are functionally conserved DNA-protein complexes that are situated throughout the genome and organize independent transcriptional domains.  Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the mechanisms by which RNA affects insulat...
ORGANISM(S): Drosophila melanogaster 
2013-01-29 | E-GEOD-41950 | biostudies-arrayexpress
UnknownIntegrative Metabolomics and Proteomics Detected Hepatotoxicity in Mice Associated with Alkaloids from Eupatorium fortunei Turcz.
Not available
S-EPMC9698670 | biostudies-literature
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