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TranscriptomicsChromatin immunoprecipitation with p53-antibody of human osteosarcoma cell line Saos-2 infected with adenomviruses encoding GFP, or GFP with p53 H1 helix mutants EL or RE
ChIP-chip study using Saos-2 cell line infected with adenoviruses encoding GFP (Mock) or GFP together with the p53 H1 helix mutants EL or RE. DNA-protein-complexes were precipitated with monoclonal p53-antibody (clone DO-1). Mock-chromatin was immunoprecipitated in the absence of antibody.
Three ...
ORGANISM(S): Homo sapiens 
2010-05-13 | E-MEXP-1748 | biostudies-arrayexpress
GenomicsExon4-mutations in KRAS in Multiple Myeloma
Data Access Committee EGAC00001001432
EGAC00001001432 | EGA
TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
TranscriptomicsNatalizumab exerts direct signaling capacity and supports a pro-inflammatory phenotype in some patients with multiple sclerosis
Natalizumab is a recombinant monoclonal antibody raised against integrin alpha-4 (CD49d). It is approved for the treatment of patients with multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the CNS. Natalizumab blocks leukocyte extravasation across the blood-brain barrier by inhi...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-37783 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-IBIOS-17-08-2015-09:13:01:216-19 - samples
PAR-CLIP was performed on the Argonaute-2 protein (AGO2) in four lymphoma cell lines: Namalwa Raji SU-DHL-4 SU-DHL-6
EGAD00001001468 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-16-11-2015-13:05:39:993-4 - samples
Part of WGS seq data of Maligant Lymphoma study (ICGC)
EGAD00001001673 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-16-09-2015-13:05:30:578-414 - samples
After overexpression and knockdown of both described novel miRs nmiR-1 and nmiR-2 in BL cell lines (SU-DHL4 for nmiR-1 and Raji for nmiR-2), we performed regular RNA-Seq (including Mock controls for all cell lines) to identify their direct and indirect downstream mRNA targets.
EGAD00001001612 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-06-10-2015-14:15:14:065-198 - samples
miRNA seq data of 13 cases (MMML)
EGAD00001001632 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-16-11-2015-12:46:40:494-3 - samples
Part of RNA sequencing data of Malignant Lymphoma Study (ICGC)
EGAD00001001672 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-23-09-2015-12:28:32:695-418 - samples
miRNA seq data of 43 cases out of dataset EGAD00001000650 (MMML)
EGAD00001001619 | EGA
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