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UnknownMutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome.
Not available
S-EPMC4373692 | biostudies-literature
TranscriptomicsOXPHOS complex I deficiency leads to transcriptional changes of the Nrf2-Keap1 pathway and selenoproteins.
Defective complex I (CI) is the most common type of oxidative phosphorylation (OXPHOS) disease in patients, with an incidence of 1 in 5,000 live births. Complex I deficiency can present in infancy or early adulthood and shows a wide variety of clinical manifestations, including Leigh syndrome, (card...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27041 | biostudies-arrayexpress
UnknownAssociation of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans.
Not available
S-EPMC3299842 | biostudies-literature
UnknownA phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma.
Not available
S-EPMC6006836 | biostudies-literature
UnknownA randomised trial of the effect of postal reminders on attendance for breast screening.
Not available
S-EPMC5154292 | biostudies-literature
ProteomicsRapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment Analysis
Reliable, robust, large-scale molecular testing for SARS-CoV-2 is essential for monitoring the ongoing Covid-19 pandemic. We have developed a scalable analytical approach to detect viral proteins based on peptide immunoaffinity enrichment combined with liquid chromatography - mass spectrometry (LC-M...
ORGANISM(S): Homo Sapiens Severe Acute Respiratory Syndrome Coronavirus 2 
2021-11-15 | PXD026366 | panorama
ProteomicsGlobal phosphoproteomics for CRISPR/Cas9 mediated PTPN22 Ser325 mutagenesis on Jurkat cells
LQF of 3x FLAG PTPN22 WT Jurkat cells compared to S325A and S325E KI mutant Jurkat cells. WT or KI lines were stimulated with or without TCR engagement for 5 min.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-21 | MSV000093718 | MassIVE
ProteomicsImmunoprecipitated PTPN22 Phosphoproteomics from Jurkat Cells
3x FLAG tagged PTPN22 were immunoprecipitated from Jurkat cells stimulated by TCR for 5min, and the proteins were eluted by FLAG peptides. This study aims to explore the phosphorylation sites on PTPN22 phosphatase, identifying two phosphorylation sites Ser325 and Ser449.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-21 | MSV000093717 | MassIVE
UnknownInterventions on gender equity in the workplace: a scoping review.
Not available
S-EPMC10998304 | biostudies-literature
ProteomicsA pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease
Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. Nat Biotechnol. 2011, 29(7):635-43. doi: 10.1038/nbt.1899. PMCID:PMC3366591. Discovery, AIMS, and MRM datasets Discovery_Tranche_hash: b/quYtp/Q8fY...
2013-12-19 | MSV000078513 | MassIVE
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