Sort   by:  
 Page size 
TranscriptomicsTbx3 controls Dppa3 levels to regulate exit from pluripotency towards mesodermal lineage
Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs). However, we show that mESCs exist in an alternate stable pluripotent state in the absence of Tbx3. In-de...
ORGANISM(S): Mus musculus 
2015-07-21 | E-GEOD-60066 | biostudies-arrayexpress
TranscriptomicsModeling Familial Cancer with iPSC Approaches
In vitro modeling of human disease has recently become feasible with the adoption of induced pluripotent stem cell (iPSC) technology. Here, we established patient-derived iPSCs from an Li-Fraumeni Syndrome (LFS) family and investigated the role of mutant p53 in the development of osteosarcoma (OS). ...
ORGANISM(S): Homo sapiens 
2015-04-10 | E-GEOD-58123 | biostudies-arrayexpress
Sort   by:  
 Page size